PC group

The first trimethy1enephosphate (62) has a planar PCs group with three very similar CPC bond angles.143 Studies of the charge distribution will be interesting. 

Since the PC group is a polar head of a major lipid component of the cell membrane of red blood cell which is the only nonadherent cell among various blood cell types, a biomimetic approach to incorporating the PC group on the surface at the terminal end of water-soluble graft polymers has been... 

Experimental hearts of the PC group (group I) were equilibrated for 10 min and subsequently exposed to 2 min of global ischemia followed by 3 min reperfusion. This process was repeated 3 times. Preconditioned hearts were then subjected to global ischemia (for 18,25,35,45,52,60 min) followed by 20 min of reperfusion. 

Table 1 depicts the values of several hemodynamic parameters at the end of 20 min reperfusion (as % of the pre-ischemic value), after ischemia of increasing duration (18-60 min). A time-dependent decrease in these parameters was observed for both group I and III (PC+ischemia and the ischemia without PC). Group III hearts, after 35 min ischemia, lost most (60-80%) of their function, while after 45 min the loss was complete. 

P (Fi Fj Fj) - JobacW Pc Factor - Equation Oriented Technique P () - Joback Pc - Group Contribution Technique... 

PhosphorylctK ine (PC) group takes internal salt structure stably with 6-alo>ms ring structure. 

In the field of biomimetic chemistry, phospholipid molecules have been utilized for the preparation of cell membrane-like stractures, namely, liposomes and Langmuir-Blodgett membranes. However, a major disadvantage of molecular assemblies of this kind is their inadequate chemical and/or physical stability. Stabilization of the phospholipid assembly is therefore an important topic of focus in the construction of interfaces between living and artificial systems. One approach to addressing this issue is the design of a new type of polymer system with PC groups. 

Several studies that involve the introduction of PC groups to a PU surface have been performed. They are summarized in Table 11.1. 

Table 11.1 Surface modifications on polyurethanes by introduction of phosphorylcholine (PC) group... 

Surface reaction on PEU with PC group Platelet adhesion [91]... 

PUU with PC group introducing during polyaddition Platelet adhesion [96]... 

Simple modification is performed by utilizing reactive compounds with a PC group. The compounds can react with the PU surface and form chemical bonds. When this occurs, the mechanical properties of the base PU should not be affected by the reaction procedure. One of the ideal procedures is the utilization of a photochemical reaction. 

Kool et al. prepared PC compounds with a phenylazide group as a photoreactive moiety [83,84]. They synthesized molecules containing a photoinduced reactive 4-azidobenzoyl group at one end of the molecule and a PC group at the other end (Figure 11.7). 

Polyaddition with diol compounds with a PC group... 

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