Pathogenesis intestinal tract

The pathogenesis of alcoholic liver disease is a multifactorial process involving metabolic repercussions of ethanol oxidation in the liver, dysregulation of fatty acid oxidation and synthesis, and activation of the innate immune system by a combination of direct effects of ethanol and its metabolites and by bacterial endotoxins that access the liver as a result of ethanol-induced changes in the intestinal tract. Tumor necrosis factor- , a proinflammatory cytokine that is consistently... 

Torres A, Serra-Battles J, Ros E, Piera C, Puig de la Bellacasa J, Cobos A, et al. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation the effect of body position. Ann Intern Med 1992 116 540-542. Bonten MJM, Gaillard CA, de Leeuw PW, Stobberingh EE. The role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia. Clin Infect Dis 1997 24 309-319. 

Tochowioz (110) agreed mth Font and Thivolle that some of the trouble in pernicious anemia lies in faulty protein metabolism. He found not only impaired absorption of amino acids from the gastro-intestinal tract, in pernicious anemia, but lessened retention of the amino acids by the tissues and their increased elimination in the urine. From the results of blood studies of normal people as well as those suffering from posthemorrhagic and pernicious anemias, he concluded that although tryptophane may play some role in Biermer s anemia, histidine is of no importance in either the pathogenesis or the treatment of the disease. 

Peptide ulcer disease (PUD) is a group of upper Gl tract disorders that result from the erosive action of acid and pepsin. Duodenal ulcer (DU) and gastric ulcer (GU) are the mou common forms, although PUD may occur in the esophagus or small intestine. Factors involved in the pathogenesis and... 

Pathogenesis of salmonellosis involves the following stages. After the entry of pathogen in the gastrointestinal tract, it adheres to epithelial cells of intestinal mucosa and generates endotoxin by activation of cyclic adenosinomonophosphate (cAMP), which causes electrolyte and water secretion from plasma to lumen. Bacterial infiltration of intestinal mucosa and inflammation contributes to diarrhea, the main clinical manifestation. 

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