PathFinder program

Plate 15 MIF transformation obtained with PathFinder program. Left, the transformation for the NAD site of the protein L-aspartate oxidase. Right, the MIF transformation for the NAD ligand molecule alone. The two maps are very similar, although the NAD molecule was roto-translated from the initial true position. The map comparison obtained from PathFinder can substitute virtual docking procedures. 

We would like to thank the M. Hann group (GSK, Stevenage, UK) for granting funds to the research projects in the PathFinder program, our team of coworkers in Perugia and Molecular Discovery (London) for support in implementing the programs. 

New exploration techniques, and new reference materials in support of them, were needed. One major change was in the use of ore pathfinder elements, rather than the ore elements themselves, for exploration purposes. For example, instead of analyzing samples for the primary Au ore element, samples were analyzed for As, Hg, and W pathfinders that pointed to hidden gold deposits. The pathfinder elements occur in association with ore veins, but have a much broader spread than the mineralized area itself. However, measurement of the pathfinder elements requires methods with better detection limits than were needed in earlier exploration programs, as the pathfinders typically are not as enriched as the ore elements, in comparison to baseline crustal levels. 

Elements chosen from the limited NURE multi-element geochemical packages that may be pathfinders for porphyry-style deposits (Lefebure Ray 1995) include Ba, Co, Cu, Mn, Pb, Ti, V, and Zn. Under the NURE program, two analytical techniques were used energy dispersive x-ray fluorescence (Cu and Pb) and neutron activation (Ba, Co, Mn, Ti, V, and Zn). Single element plots and element association plots were generated. Geochemical data for pond sediments collected over the Pebble deposit in 2008... 

Ebe, Tommy, and Antonio Zamora, "PATHFINDER II, A Computer Program That Generates Wiswesser Line Notations for Polycyclic Structures," Journal of Chemical Information and Computer Sciences, 16( 1), 36-39 (1976). 

The PathFinder descriptors were pretreated using block-unweighted (BUW) scales, as available in the Golpe program [7], using the following BUW scales ... 

The GRID force field represents the basis for several software packages specifically developed for application to pharmacodynamic aspects of drug research, including the programs ALMOND, Pathfinder, and FLAP or, in the ADME field, the programs VolSurf and MetaSite. 

NASA, NOAA/NASA Pathfinder AVHRR Land (PAL) Program, 1996. 

Under the USAEC program, the following reactors were built Boiling Reactor Experiment V (BORAX—V, started operation in December of 1962), BOiling NUclear Superheater (BONUS, started operation in December of 1964), and Pathfinder (started operation in July of 1966). The main parameters of these reactors are listed in Tables A5.1 and A5.2 (Novick et al., 1965). 

Ross, W.B., 1961. Pathfinder Atomic Power Plant, Superheater Temperature Evaluation Routine, an IBM-704 Computer Program. United States Atomic Energy Commission, Office of Technical Information, Oak Ridge, TN, 49 pp. 

Nomex was and still is widely used in the U.S. space programs, for instance, in the form of airbags for the Mars-Pathfinder and Mars-Exploration-Rover missions. 

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