Pars, Harry

Chemical Corps interest in cannabinoids came alive when an analog of THC, code named EA 2233, emerged from the laboratories of Arthur D. Little under the supervision of chemist Harry Pars. Before proceeding to a summary of the experiments we carried out with EA 2233 in late 1961, a brief detour back to the future is appropriate. 

Poor Harry In response to what must have been a withering barrage of questions from reporters, he at first conceded that the Arthur D. Little firm regularly accepted substantial government contracts involving secret work. He then made the disastrous admission that he might occasionally fend off a questioner to protect a secret project. If I had a contract with anybody - well, our clients are held in confidence unless they themselves want to disclose, Dr. Pars said. I think that s an Arthur D. Little policy. ... 

Department of Defense is or is not doing...I m certainly not going to go out of my way to disclose things about Department of Defense work. R.I.P., Harry Pars ... 

Meanwhile, back at the lab, volunteer experiments in 1961 were ramping up and beginning to operate at full tilt. When Harry Pars supplied us with a synthetic analog of THC for clinical testing, it came as a mixture of eight stereoisomers. (Stereoisomers are different spatial conformations of the same molecule.) It was not yet feasible to separate the eight isomers for our first studies and consequently, we could not yet explore the relative potency of each of them individually. 

Greenland DG, Hayes MHB (1981) The chemistry of soil constituents. WUey, New York Harris RF (1981) Effect of water potential on microbial growth and activity. In Par J et al. (eds) Water potential relations in soil microbiology. Soil Science Society of America, Madison, Wl. 

Pars HG, Granchelli FE, Razdan RK, Keller JK, Teiger DG, Rosenberg FJ, Harris LS (1976) Drugs derived from cannabinoids. 1. Nitrogen analogs, benzopyranopyridines and benzopyranopyrroles. J Med Chem 19 445-454... 

Lorris, Guillaume de and Jean de Meun. Leroman de la rose (ca. 1230—40 [Guillaume], ca. 1280 [Jean]). Three editions were consulted. (1) Ernest Langlois, ed., Le roman de la rose par Guillaume de Lorris et Jean de Meun, 5 vols. (Paris Edouard Champion, 1914—1924). (2) Harry W Robbins, trans., The Romance of the Rose (New York E. P. Dutton, 1962). (3) Andre Lanly, trans., Le roman de la rose, 2 vols. (Paris Librairie Honore Champion, 1971-1982). 

Polyarylethersulfone (-[0-(t)-0-(t)-S02-(t)-]Q 2s -[-0-(t)-S02-(t)-]Q 75jj-) (PAES) blended with either PAr, PEST, PC, or their mixtures showed well-balanced mechanical properties and good environmental stress cracking resistance [Robeson and Harris, 1985, 1986]. For improvement HDT, mechanical properties and flame retardancy, PET was blended with a PAES (-[- (t)-S02-(t)-0-(t)-C(CH3)-(t)-0] -) [El-Hibiri et al., 1992]. Blends of this type PAES with PC, PET, ZnBOj, and PTFE had high flame retardancy [Jack et al., 1993]. 

PAES with PC, PAr or PEST well-balanced mechanical properties Robeson Harris, 1985-86... 

Additional polymer blends comprising PAEK s offering property combinations of potential utility include PSF [Robeson and Harris, 1986 Harris and Robeson, 1989] structurally different poly(aryl ketones) [Harris and Robeson, 1986], PAr [Robeson and Harris, 1992], poly(amide-imide) PAI [Harris and Gavula, 1992], PPS [Robeson, 1987], and other PI [Harris et al., 1992]. Mixtures of structurally different PAEK s were noted to be isomorphic within specific limits of ether/ketone ratios [Harris and Robeson, 1987]. Blends of polybenzimidazole, PBI and several commercial PI (Ultem 1000 and Matrimid 5218) have been studied in depth at the University of Massachusetts and found to be miscible. FTIR studies [Guerra et al., 1988 Kim et al., 1993], NMR studies [Grobelny et al., 1990], thermal, dielectric, and mechanical... 

Flgure4.11 Synergistic impact strength behavior of PEEK/PAR blends(reproducedfrom Harris,J.E.and Robeson, L. M., in Contemporary Topics in Poiymer Science, Voi.6, Multiphase Macromolecuiar Systems, Cuibertson, B. M. (Ed.) (1989) Plenum Press, New York with kind permission of Springer Science and Business Media)... 

---