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Parallel phase separation

Merritt et al. [1] and others [15] have disclosed a number of techniques for parallel phase separation which facilitates the aqueous washing of crude products. The initial approach used a commercially available hydrophobic membrane in a polypropylene cartridge to separate a chlorinated solvent from an aqueous phase. An alternative liquid solid extraction involving an absorbent packing has also been used by workers at Arris Pharmaceuticals in the preparation of triazine libraries [16]. [Pg.4]

Recently, due to increased interest in membrane raft domains, extensive attention has been paid to the cholesterol-dependent liquid-ordered phase in the membrane (Subczynski and Kusumi 2003). The pulse EPR spin-labeling DOT method detected two coexisting phases in the DMPC/cholesterol membranes the liquid-ordered and the liquid-disordered domains above the phase-transition temperature (Subczynski et al. 2007b). However, using the same method for DMPC/lutein (zeaxanthin) membranes, only the liquid-ordered-like phase was detected above the phase-transition temperature (Widomska, Wisniewska, and Subczynski, unpublished data). No significant differences were found in the effects of lutein and zeaxanthin on the lateral organization of lipid bilayer membranes. We can conclude that lutein and zeaxanthin—macular xanthophylls that parallel cholesterol in its function as a regulator of both membrane fluidity and hydrophobicity—cannot parallel the ability of cholesterol to induce liquid-ordered-disordered phase separation. [Pg.203]

At higher concentrations, micelles assemble in turn, to form hexagonal or cubic phases while longer chains or multi-chain compounds afford lamellar phases in which the amphiphilic derivative is arranged in parallel bilayers, separated by water. The succession of mesophases depending on temperature and concentration of the amphiphile can be visualized in a phase diagram (Fig. 3 c). [Pg.281]

The extensive studies of the behavior of mixed monolayers or bilayers of di-acetylenic lipids and other amphiphiles parallel to some degree the studies of dienoyl-substituted amphiphiles. Since the dienoyl lipids do not contain a rigid diacetylenic group in the middle of the hydrophobic chains, they tend to be miscible with other lipids over a wide range of temperatures and compositions. In order to decrease the lipid miscibility of certain dienoyl amphiphiles, Ringsdorf and coworkers utilized the well-known insolubility of hydrocarbons and fluorocarbons. Thus two amphiphiles were prepared, one with hydrocarbon chains and the other with fluorocarbon chains, in order to reduce their ability to mix with one another in the bilayer. Of course it is necessary to demonstrate that the lipids form a mixed lipid bilayer rather than independent structures. Elbert et al. used freeze fracture electron microscopy to demonstrate that a molar mixture of 95% DM PC and 5% of a fluorinated amphiphile formed phase-separated mixed bilayers [39]. Electron micrographs showed extensive regions of the ripple phase (Pb phase) of the DM PC and occasional smooth patches that were attributed to the fluorinated lipid. In some instances it is possible to... [Pg.64]

I Bulk separation in the three-phase separators is possible in cither scries mode or parallel mode. [Pg.22]

The combination of the catalytic method and the three-phase separation could be applied to the parallel rapid synthesis of a small library of nine compounds of type 7 using the Giese reaction (eq. 5.3). The attractive prospect from this simple experiment arises from the very efficient workup protocol, allowing facile and quantitative separation even if excess reagents... [Pg.90]

A process for phase separation based on density differences. A commercial lamella settler for suspensions or emulsions comprises a stack of parallel plates spaced apart from each other and inclined from the horizontal. The space between each set of plates forms a separate settling zone. The feed is pumped into these spaces, at a point near the longitudinal middle of the plates. The less dense phases rise to the underside of the upper plates... [Pg.379]


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Parallel separations

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