Tablet manufacture paracetamol

The true direct compression process as described earlier almost invariably applies to formulations containing potent active ingredients and where the direct compression properties derive from the diluent. A few substances do possess adequate flow and cohesive properties without the need for pretreatment. These are usually crystalline inorganic salts such as sodium chloride and potassium chloride. Direct compression forms of less potent active ingredients are available e.g., paracetamol and ascorbic acid. These can be directly compressed into tablets, perhaps after the addition of a lubricant. However, such substances are more accurately described as pre-granulated, in that the granulation process—either wet granulation or precompression—has been carried out by the excipient manufacturer. 

Said et al. [52] used PCA and SIMCA to compare paracetamol tablets made in the UK and in Malaysia and to evaluate the manufacturing variability existing between the two countries. They proposed the approach... 

The final product flowabilily, compressabilty, and compaction depend on the mechanical properties and morphologies of the crystalline form. The fact that these properties are different for different polymorphs suggests that the manufacturability of a drug product depends on the polymorphic state. The effect of polymorphism on tableting of ibuprofen and acetaminophen has been studied. It was found that crystal habit affects drug flowability. Polymorphs of paracetamol show different compressability. Form II being easier to compress as a tablet. 

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