Pantothenic acid factors affecting

The uptake and accumulation of various amino acids in Lactobacillus arabinosus have been described. Deficiencies of vitamin B6, biotin, and pantothenic acid markedly alter the operation of these transport systems. Accumulation capacity is decreased most severely by a vitamin B6 deficiency. This effect appears to arise indirectly from the synthesis of abnormal cell wall which renders the transport systems unusually sensitive to osmotic factors. Kinetic and osmotic experiments also exclude biotin and pantothenate from direct catalytic involvement in the transport process. Like vitamin B6, they affect uptake indirectly, probably through the metabolism of a structural cell component. The evidence presented supports a concept of pool formation in which free amino acids accumulate in the cell through the intervention of membrane-localized transport catalysts. 

Fatty acids and alcohols are products of yeast metabolism but the uncatalysed rate of chemical reaction between these substances is 1000 times too slow to account for ester formation in fermentation. Pantothenic acid (a precursor of coenzyme A) stimulates ester production [79] and factors which influence acetyl CoA metabolism affect ethyl acetate synthes s [77]. The biosynthesis of esters in yeast was therefore proposed to occur by the alcoholysis of acyl CoA compounds [77]. The alcohols involved in these reactions are ethanol and the fusel alcohols. The acyl CoA molecules used may be derived in one of several ways ... 

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