Pancreatic spasmolytic polypeptid

The effect of various peptides and growth factors in small cell lung cancer cells has been reported by Bepler et al [121]. Four peptides isolated from completely different sources with structural similarities represent members of a new family of growth factors [121]. These peptides include 1) a 60 amino acid residue breast cancer- associated pS2 peptide isolated from human gastric juice and the culture media of the human breast cancer cell line MCF-7, 2) a 106 amino acid residue pancreatic spasmolytic polypeptide (PSP) isolated from porcine pancreas and 3) a 49 and 50 amino acid residue peptide predicted from a cyclic DNA isolated from the skin of frog, Xenopus laevis. [Pg.805]

The antiproliferative effect of Acetyl-N-Ser-Asp-Lys-Pro inhibitor of hematoporetic stem cell proliferation has been also reported [127]. Fibrinogen-like peptides have been reported to show anti cancer activity as well [128]. The identification of growth factors-like peptides with structures with common features of the known anticancer peptide (pS2), the pancreatic spasmolytic polypeptide (PSP) and frog skin peptides (spasmolysins) has been reported by Thim [129]. [Pg.806]

Hoffmann, W., 1988, A new repetitive protein from Xenopus laevis skin highly homologous to pancreatic spasmolytic polypeptide, J. Biol. Chem. 263 7686-7690. [Pg.188]