Anticancer peptide

VM2 GLFDKLKSLVSDFXd 14 Anticancer peptide design based on the N-terminal sequence of E. coli enzyme IIA (glucose)... 

CBla, novel anticancer peptide derived from natural AMP cecropin B Jingzhaotoxin-VII... 

The antiproliferative effect of Acetyl-N-Ser-Asp-Lys-Pro inhibitor of hematoporetic stem cell proliferation has been also reported [127]. Fibrinogen-like peptides have been reported to show anti cancer activity as well [128]. The identification of growth factors-like peptides with structures with common features of the known anticancer peptide (pS2), the pancreatic spasmolytic polypeptide (PSP) and frog skin peptides (spasmolysins) has been reported by Thim [129]. 

Anticancer peptides have attracted concern recently due to their characteristics features such as multifunction, high sensitivity, and stability. There are number of publications on anticancer peptides from food protein, such as fish sauce (Lee et ah, 2004), soy protein (Kim et ah, 2000),... 

Leng, B., Liu, X. D., and Chen, Q. X. (2005). Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes. FEBS Lett. 579,1187-1190. 

Strategies for improving the efficacy of anticancer peptides peptidomimetics and delivery options 283... 

Magainin-2 and its analogs were found in 1993 to display sdective cytotoxidty toward carcinoma cdls in vitro and were proven to be as effective as doxorubidn in vivo via intrapetito-neal deUvety in ovarian cancer mouse modds. Several other anticancer peptides were also later found to exhibit selective cytotoxidty toward cancer cell lines in vitro, with RBCs, primary cells, or 3T3 fibroblasts generally tested as normal controls. However, even now, the selectivity of these cationic, amphipathic peptides toward cancer cells is still not well understood. 

To further improve the selectivity of these cationic, amphipathic anticancer peptides, homing/targeting moieties have been attached to them. Homing moieties are suitable for developing anticancer therapeutic and diagnostic agents due to their selectivity toward tumor cells or tumor vasculature. Many of... 

Gaspar D, Veiga AS, Castanho MARB. From antimicrobial to anticancer peptides. A review. Front Microbiol 2013 4 1-16. 

Wu JM, Jan PS, Yu HC, Haung HY, Fang HJ, Chang YI, Cheng JW, Chen HM (2009) Structure and function of a custom anticancer peptide, CBla. Peptides 30 839... 

O. Pando, S. Stark, A. Denkert, A. Porzel, R. Preusentanz, L. A. Wessjohann, J. Am. Chem. Soc. 2011, 133, 7692-7695. The multiple multicomponent approach to natural product mimics tubugis, N-substituted anticancer peptides with pico-molar activity. 

For recent examples of the synthesis of peptides and peptoids by the Ugi 4-CR, see (a) O. E. VerciUo, C. K. Z. Andrade, L. A. Wessjohann, Org. I tt. 2008, 10, 205-208. Design and synthesis of cychc RGD pentapeptoids by consecutive Ugi reactions, (b) O. Pando, S. Stark, A. Denkert, A. Porzel, R. Preusentanz, L. A. Wessjohann, J. Am. Chem. Soc. 2011, 133, 7692-7695. The multiple multicomponent approach to natural product mimics tubugis, V-substituted anticancer peptides with picomolar activity, (c) A. Fatima, S. Barreto, O. E. Vercillo, M. A. Birkett, J. C. Caulfield, L. A. Wessjohann, C. K. Z. Andrade, Org. Biomol. Chem. 2011, 9,5024-5027. Fast and efficient microwave-assisted synthesis of functionalized peptoids via Ugi reactions, (d) M. Abbas, L. A. Wessjohann, Org. Biomol. Chem. 2012, 10, 9330-9333. Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction. For an application to peptide-peptoid podands by threefold Ugi-4CRs, see (e) D. G. Rivera, F. Leon, O. Concepcidn,... 

Dolastatin 10 Phase II Dolabella auricularia anticancer Peptide... 

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