Pancreatic hypersecretion

Acid hypersecretion inactivating pancreatic enzymes Iatrogenic... 

Mukawa K, Kawa S, Aoki Y, et al. Reduced expression of p53 and cyclin A in intraductal mucin-hypersecreting neoplasm of the pancreas compared with usual pancreatic ductal adenocarcinoma. Am J Gastroenterol. 1999 94 2263-2267. 

Satoh K, Sawai T, Shimosegawa T, et al. The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas. Int J Pancreatol. 1993 14 135-143. 

Green, G. M., and Lyman, R. L., 1972, Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor induced hypersecretion in rats, Proc. Soc. Exp. 

Further correlations between gastroduodenal ulceration and other related conditions noted the association of pancreatic tumors with peptic ulceration. The further elucidation of the neuroendocrine tumor source of gastrin and the consequences of acid hypersecretion led to the resolution of this relationship by Zollinger and Ellison. They identified the existence of a syndrome of pancreatic neuroendocrine tumors associated with a peptic ulcer diathesis. Similar observations in conditions such as basophil leukemia and mastocytosis noted the excessive production of histamine with consequent acid hypersecretion and peptic ulcer disease in such patients. 

Malabsorption associated with (a) a deficiency of pancreatic enzymes or bile, (b) infiltration of the small intestine by the cancer, (c) gastric hypersecretion as in the Zollinger-Elli-son syndrome, (d) blind loop syndrome caused by obstruction in upper part of the small intestine, or (e) hypopitisia— regression of the villi of the small intestine. 

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