Pancreatic head carcinoma

Takada T, Yasuda H, Amano H et al (1997) Simultaneous hepatic resection with pancreato-duodenectomy for metastatic pancreatic head carcinoma does it improve survival Hepatogastroenterology 44 567-573... 

A pancreatic head carcinoma will bulge into and deform the medial wall of the duodenum, both above and below the level of the ampulla. This may be severe enough to prevent the passage of an endoscope. 

Satoh K, Sawai T, Shimosegawa T, et al. The point mutation of c-Ki-ras at codon 12 in carcinoma of the pancreatic head region and in intraductal mucin-hypersecreting neoplasm of the pancreas. Int J Pancreatol. 1993 14 135-143. 

Pancreatic carcinoma most frequently involves the head of the gland and usually presents with obstructive jaundice. About 10% of patients with pancreatic head cancer develop duodenal obstruction, usually quite late on in the course of their disease. Therefore most patients developing duodenal obstruction from pancreatic cancer will already have a biliary stent in... 

Fig.7.47a,b. 67-year-old man after multivisceral transplantation necessitated by liver cirrhosis with intrahepatic hepatocellular carcinoma and chronic thrombotic occlusion of portomesenteric venous system with clinical evidence of infection. a Contrast-enhanced helical CT obtained 2 weeks after operation shows enlargement of pancreatic head with reduced contrast enhancement (white arrow) consistent with edematous pancreatitis. Annotation ascites (black asterisk), gastric tube (white arrowhead), periportal lymphedema (black arrow), stomach (white asterisk), b Contrast-enhanced helical CT obtained 4 weeks after operation displays unspecific enlargement of mesenteric lymph nodes (arrow) of intestinal graft. Annotations ascites (asterisk), calcification of iliac artery (arrowhead)... 

In the dose-escalation studies, PK data were obtained for patients with a variety of EGFR-expressing solid cancers, while the studies at the approved dosing regimen were conducted in the indications of colorectal carcinoma, squamous cell cancer of the head-and-neck, pancreatic cancer, and renal cell cancer. 

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