Pan coating process

For a side-vented pan-coating process, the processing data shown in Table 7 exemplify some spray rates that may well be used during process scale-up. It is interesting to note from these data that the drying (and... 

From the foregoing discussion, there are clearly many issues to be confronted when scaling up the pan-coating process. Evidently, the more definitive data that are developed initially, the less likely that major problems will occur later on, especially problems that could inevitably delay a product launch and cost much in the way of lost revenues, particularly when dealing with a potentially blockbuster drug product. 

This case study will summarize the development of a pan-coating process designed for the application of an enteric coating to a tablet product, provide insight into some of the early process optimization studies that were undertaken, and show how these ultimately facilitated the development of production-scale manufacturing processes. 

In contrast to pan-coating processes, some characteristics of fluid-bed processes that may feature strongly in the scale-up process include the fact that ... 

Summary of scale-up issues Scaling-up the fluid-bed process clearly faces many hurdles that are both similar and, at the same time, different from those faced with pan-coating processes. Additional complexity stems from the nature of the substrate that is likely to be coated in the fluid-bed process, as well as the fact that, very often, the applied coating has a very important role to play in drug delivery. 

Figure 18 Schematic diagram of a continuous pan-coating process.

The basic differences between the various fluidized bed techniques and the perforated pan coating process will be elucidated. The coating methods described have common process variables. Alt require application of liquid, evaporation of the coating media and mixing of the core material to assure uniform distribution of the material being applied. These variables and their influence on product quality and the process will be discussed in detail. 

In the pan coating process, a coating material is sprayed onto a particulate ( 800 pm) mass tumbled in a mixer, forming coated particles. The process is used by the pharmaceutical industry to produce... 

Pan-coating can potentially be used to apply a film coat on any particulate material that can be confined to a coating pan and be coated. Beyond that, the applied coating system must be applicable to the critical process requirements such as particle size, coat solution viscosity, drying requirements, coat properties, and final product attributes. This section provides a general overview of applications and application considerations for pan-coating processes. 

It is difficult to foresee all the potential problems that can be realized in a pan-coating process. Problems can be related to formulation shortcomings, process limitations, or suboptimal process parameters. Once a coat formulation has been established, there may not be opportunity to adjust composition depending on regulatory restrictions thus, it may be prudent to optimize to a robust formulation before the adjustment period passes. The following characteristics should be included in such a formulation assessment ... 

Pandey P, Turton R, Joshi N, Hammerman E, and Ergun 1. Scale-up of a pan-coating process. AAPS PhamScieTech (2006) 7(4), E1-E8. 

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