Coating pans

Tetrafluoroethylene Teflon Gaskets, insulation, bearings, pan coatings... 

Many sweets (confections) must be colored, a strong point in their attractiveness for consiuners. The commonly colored products are candies (starch jellies, candy cream centers, pan-coated candies, and hard candies), tablets, wafers, oil-based coatings, and chewing gmns. 

Colorants must be introduced into the coating syrups during production of pan-coated candies. Water-soluble colorants may be used but lake pigments as dispersions are preferred. Pan-coated candies require higher concentrations of colorants than jellies or creams they require 30 to 60 coatings of colored syrup. ... 

Fluidized beds, in general, and the air-suspension technique patented by Wurster, in particular, now offer an attractive alternative to pan coating. The basic principle underlying their operation is to suspend the... 

Figure 1 Schematic diagram highlighting the basic concepts of pan-coating equipment.

For a side-vented pan-coating process, the processing data shown in Table 7 exemplify some spray rates that may well be used during process scale-up. It is interesting to note from these data that the drying (and... 

From the foregoing discussion, there are clearly many issues to be confronted when scaling up the pan-coating process. Evidently, the more definitive data that are developed initially, the less likely that major problems will occur later on, especially problems that could inevitably delay a product launch and cost much in the way of lost revenues, particularly when dealing with a potentially blockbuster drug product. 

This case study will summarize the development of a pan-coating process designed for the application of an enteric coating to a tablet product, provide insight into some of the early process optimization studies that were undertaken, and show how these ultimately facilitated the development of production-scale manufacturing processes. 

In contrast to pan-coating processes, some characteristics of fluid-bed processes that may feature strongly in the scale-up process include the fact that ... 

Summary of scale-up issues Scaling-up the fluid-bed process clearly faces many hurdles that are both similar and, at the same time, different from those faced with pan-coating processes. Additional complexity stems from the nature of the substrate that is likely to be coated in the fluid-bed process, as well as the fact that, very often, the applied coating has a very important role to play in drug delivery. 

Figure 18 Schematic diagram of a continuous pan-coating process.

Pan coating with a Eudragit-PEG 400 mixture proved to be best technique. The relative ease of manufacture and the variety of release profiles attainable make pan coating with a Eudragit E 300-PEG 400 mixture a useful technique for obtaining sustained release tablets. Further studies will be necessary to assess the influence of Eudragit PEG ratio on ketoprofen release characteristics. 

As with pan coating, the key to successfully scaling up the fluid bed process involves the design of a completely optimized laboratory-scale process on which key decisions can be based. As discussed earlier, Turkoglu and Sakr [8] have provided an appropriately relevant example of how such an optimized fluid bed process (in this case, a tangential-spray process) may be designed. 

Pan Coating Conventional Coating Bruck System O Hara Pellegrini Stokes-Merrill... 

Pan coating subclasses primarily are distinguished by the pan configuration, the pan perforations, and/or the perforated device used to introduce process air for drying purposes. Perforated coating systems include both batch and continuous coating processes. 

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