PAMAM dendrimers biological structures

These dendrimers have been additionally modified with biologically active molecules, which can react with the available amidic functional groups. Result from the first photophysical and biochemical investigations of the new structurally modified dendrimers are discussed. The comparison between the bio-modified PAMAM dendrimers and some linear polymers is given (Grabchev et al. 2007a). 

Further evidence to support the role of self-assembly in divergent dendrimer synthesis can be found in the construction of poly(amidoamine) PAMAM dendrimers. First, ideality and fidelity of structure is usually a signature of a self-assembly event. This is a universal observation throughout biological systems. In all cases, nearly ideal PAMAM structures are obtained only under mild conditions favoring such organizational events as a prerequisite to bond formation [88]. Attempts to impose more severe reaction conditions (i.e., reaction temperature >40 C) dramatically reduces the ideality of dendrimer structures even in the early generations. Under mild, kinetically favorable reaction conditions however, nearly ideal dendrimer structures are obtained up to the onset... 

Roberts, J.C. Bhalgat, M.K. Zera, R.T. Preliminary biological evaluation of polyamidoamine (PAMAM) star-burst dendrimers. J. Biomed. Mater. Res. 1996, 30, 53-65. Malik, N. Wiwattanapatapee, R. Klopsch, R. Lorenz, K. Frey, H. Weener, J.W. Meijer, E.W. Paulus, W. Duncan, R. Dendrimers relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of l-Labeled polyamidoamine dendrimers in vivo. J. Control. Release 2000, 65, 133-148. 

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