Palladium complexes synthesis bearing

When the Pd bears chiral ligands, these reactions can be enantioselective.1448 ir-Allylmo-lybdenum compounds behave similarly.1449 Because palladium compounds are expensive, a catalytic synthesis, which uses much smaller amounts of the complex, was developed. That is, a substrate such as an allylic acetate, alcohol, amine, or nitro compound1450 is treated with the nucleophile, and a catalytic amount of a palladium salt is added. The rr-allylpal-ladium complex is generated in situ. Alkene-palladium complexes (introducing the nucleophile at a vinylic rather than an allylic carbon) can also be used.1451... 

The palladium-catalyzed amination of aryl halides has recently emerged as a powerful alternative to other methods for the synthesis of aryl amines.5 This method allows for the cross-coupling of aryl halides arrd triflates with amines in the presence of a stoichiometric amount of a base and catalytic amounts of palladium complexes bearing tertiary phosphine ligands. As shown in Tables I and II, the Pd/BlNAP catalyst is highly effective for reactions of aryl bromides and triflates with primary and cyclic... 

Kiely, D. and Guiry, PJ. (2003) Palladium complexes of phosphinamine ligands in the intramolecular asymmetric Heck reaction. Journal of Organometallic Chemistry, 687, 546-561. Dounary, A.B., Hatanaka, K., Kodanko, J.J. et al. (2003) Catalytic asymmetric synthesis of quaternary carbons bearing two aryl substituents. Enantioselective synthesis of 3-alkyl-3-aryl... 

Polystyrene is the most frequently used polymeric support for the immobilization of palladium complexes [15]. The PS resins are well developed in the field of sohd-phase peptide synthesis. Therefore resins bearing various chemical functional groups, diameter size, loading value, degree of cross-finking, for example, are now commercially readily available to permit investigation of these variables on the catalytic property. The most widely used polystyrene in... 

Synthesis of Palladium Complexes Bearing PXP-Pincer Ligands (X = Si, Ce, Sn)... 

Ort/ o-cyclometallated palladium complexes discussed in Section 2.2.2 have found another very important application as chiral templates that promote Diels-Alder and other reactions. This chemistry has been developed by Leung and co-workers and has allowed the synthesis of an impressing number of mono- and diphosphines bearing P-stereogenic atoms with peculiar scaffolds... 

Sanchez and coworkers reported the synthesis of palladium complexes bearing two imidazolin-2-ylidene moieties linked by a chiral dioxolane backbone (Figure 4.19). This is the first example on the use of a chiral bis(NHC)-metal catalyst in asymmetric hydrogenation with high enantioselectivity [60]. 

Buchwald and coworkers reported the synthesis of nitroarenes via coupling of aryl chlorides, triflates, and nonaflates with sodium nitrate [31]. Subsequently, palladium complex bearing Mor-DalPhos L57 has been utilized for the coupling of aryl chlorides and tosylates with hydrazines (Scheme 20.16) [32]. 

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