Palladium antitumor compound

Miscellaneous. Reductioa of a palladium salt by CO is the basis of a visual test for ambieat carboa moaoxide (227). Palladium compouads are used as photographic seasitizers (228). The low dimensional mixed valeace compouad Csq g3[Pd(S2C2(CN)2)] 0.5H2O behaves as a semimetal at room temperature (229). Palladium compouads isostmctural with poteat platiaum antitumor compounds have poor antitumor activity (230). 

In respect to the Suzuki and the Negishi couplings, quinoline stannanes provide an easy entry to highly substituted derivatives. As a highlighted example, 2-trimethylstannyl-5,8-dimethoxyquinoline reacts with appropriately substituted pyridyltriflate in the presence of palladium tetrakis-(triphenylphospine), lithium chloride, and copper bromide to produce 2-pyridylquinoline, an advance intermediate for the total syntheses of antitumor compounds streptonigrin and lavendamycin. ... 

The biological activity displayed by the perhydroazulenes, ranging from diuretic and anti-inflammatory to antitumor, combined with the unique bicyclo [6-3-0] system make them very attractive synthetic targets. The approach of Trost and Higushi to this class of compounds, exemplified by the total synthesis of isoclavu-kerin 65 (Scheme 12.12) [34], has the distinctive feature that it allows the simultaneous formation of both the five- and seven-membered rings through a palladium-catalyzed formal [3+2] cyclization as its key step [35]. 

Ruiz J, Lorenzo J, Sanglas L, Cutillas N, Vicente C, Villa MD, Aviles FX, Lopez G, Moreno V, Perez J, Bautista D (2006) Palladium(II) and platinum(II) organometallic complexes with the model nucleobase anions of thymine, uracil, and cytosine antitumor activity and interactions with DNA of the platinum compounds. Inorg Chem 45 6347-6360... 

Ruiz J, Villa MD, Cutillas N, Lopez G, de Haro C, Bautista D, Moreno V, Valencia L (2008) Palladium(II) and Platinum(II) Organometallic Complexes with 4, 7-dihydro-5-methyl-7-oxo[l, 2, 4]triazolo[l, 5-a]pyrimidine. Antitumor activity of the platinum compounds. Inorg Chem 47 4490 1505... 

In vitro methods are not widely used to predict the antitumor activity of platinum compounds. Until it is determined what factors render a specific platinum-DNA adduct cytotoxic, the in vitro screens for platinum drugs will be limited. Because a good platinum drug must form DNA adducts, preliminary screening methods have been employed which measure DNA binding alone as a measure of potential antitumor activity. In one such study [13], the DNA binding of palladium and platinum complexes having inter-... 

An example prepared by tin-lithium transmetallation is compound 637, which reacts with enolizable ketones, after transmetallation with cerium(III) chloride895. This intermediate was transformed into the corresponding vinylzinc reagent and, after palladium(O)-catalyzed cross-coupling reactions with aryl iodides, was used in the synthesis of the antitumor antibiotic rineomycinone B2 methyl ester940,941. The vinyllithium 627 has also been transformed into the corresponding vinyl iodide by stannylation followed by reaction with iodine. The arylation has been performed in this case by a palladium(0)-catalyzed... 

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