Palade, George

In a major advance in biochemistry, Albert Claude, Christian de Duve, and George Palade developed methods for separating organelles from the cytosol and from each other—an essential step in isolating biomolecules and larger cell components and investigating their... 

As originally demonstrated by George Palade, proteins with these signal sequences are synthesized on ribosomes attached to the ER. The signal sequence itself helps to direct the ribosome to the ER, as illustrated by... 

Albert Claude, Christian R. de Duve, and George E. Palade Physiology/Medicine Cell structure... 

Ribosomes were first isolated by differential centrifugation and then examined by electron microscopy. This and related work by George Palade in the early 1950s earned him the Nobel prize in 1975. For a time ribosomes were known to electron microscopists as Palade s granules. 

Figure 18.1. Electron Micrograph of a Mitochondrion. [Courtesy of Dr. George Palade.]...

Electron microscopic studies by George Palade and Fritjof Sjostrand revealed that mitochondria have two membrane systems an outer membrane and an extensive, highly folded inner membrane. The inner membrane is folded into a series of internal ridges called cristae. Hence, there are two compartments in mitochondria (1) the intermembrane space between the outer and the inner membranes and (2) the matrix, which is hounded by the inner membrane (Figure 18.3). Oxidative phosphorylation takes place in the inner mitochondrial membrane, in contrast with most of the reactions of the citric acid cycle and fatty acid oxidation, which take place in the matrix. 

Figure 22.17. Electron Micrograph of a Peroxisome in a Liver Cell. A crystal of urate oxidase is present inside the organelle, which is bounded by a single bilayer membrane. The dark granular structures outside the peroxisome are glycogen particles. [Courtesy of Dr. George Palade.]...

Figure 26.15. Site of Cholesterol Synthesis. Electron micrograph of a part of a liver cell actively engaged in the synthesis and secretion of very low density lipoprotein (VLDL). The arrow points to a vesicle that is releasing its content of VLDL particles. [Courtesy of Dr. George Palade.]...

Stephen R. Adams Department of Pharmacology University of California, San Diego 310 George Palade Laboratories 0647 La Jolla, CA 92093-0647 USA Elisabetta Bianchi Immunoregulation Laboratory Department of Immunology Institute Pasteur 25, rue du Dr. Roux 75724 Paris Cedex 15 France... 

Romanian-born US physiologist George Palade (1912-2008) discovers the... 

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