Pain-induced aversion, neuronal mechanisms

NEURONAL MECHANISMS FOR PAIN-INDUCED AVERSION BEHAVIORAL STUDIES USING A CONDITIONED PLACE AVERSION TEST... 

Pain is comprised of sensory discriminative and negative affective components. Although the neural systems responsible for the sensory component of pain have been studied extensively, the neural basis of the affective component is not well understood. Recently, behavioral studies using the conditioned place paradigm have successfully elucidated the neural circuits and mechanisms underlying the negative affective component of pain. This review focuses on the behavioral studies that have used conditioned place aversion (CPA) tests to elucidate the neuronal mechanisms underlying pain-induced aversion. 

---