Packaging materials, design

A.1.2 Specifications sheet for packaging materials. —Designation of the material. 

Great care is needed in the design of autoclaves and sterilization cycles because of the requirement for the presence of moisture. The autoclave must be loaded to allow complete steam penetration to occur in all parts of the load before timing of the sterilization cycle commences. The time required for complete penetration, the so-called heat-up time, varies with different autoclave constmction and different types of loads and packaging materials. The time may not exceed specific limits in order to guarantee reproducibility and, for porous loads, saturated steam. The volume of each container has a considerable effect on the heatup time whenever fluids are sterilized. Thermocouples led into the chamber through a special connector are often employed to determine heatup times and peak temperatures. The pressure is refleved at the end of each sterilization cycle. Either vented containers must be used or... 

Cosmetics are products created by the cosmetic industry and marketed directiy to consumers. The cosmetic industry is dominated by manufacturers of finished products but also includes manufacturers who seU products to distributors as weU as suppHers of raw and packaging materials. Cosmetics represent a large group of consumer products designed to improve the health, cleanliness, and physical appearance of the human exterior and to protect a body part against damage from the environment. Cosmetics are promoted to the pubHc and are available without prescription. 

Pallets These portable platforms, on which packaged materials can be handled andstored (Fig. 21-61 shows several designs), can be... 

There shall be written procedures designed to assure that correct labels, labeling, and packaging materials are used for drug products such written procedures shall be followed. These procedures shall incorporate the following features ... 

Handling and packaging needs for batteries are different. Batteries need to be handled and packed to prevent short-circuits and minimize transportation costs. Again, a commercial company can provide appropriate packaging materials and instructions designed to minimize handling requirements and costs and eliminate possible liabilities associated with mispackaged materials. 

A great choice is available in product design and packaging material because sterilization depends on radiation penetration, which is relatively independent of the chemical composition of the packaging and product material. 

Packaging Materials (New and Existing) Design Change Control... 

New packaging materials specifications products for which the labels, leaflets, and box specifications are designed, developed, and approved for the first time. 

The changes in the test and color or design of leaflets, labels, and boxes of (in-use) packaging materials specifications are followed as stated in the change control approval matrix of the company. 

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