P 388 Mouse leukemia

Also 2 -halo-3 -hydroxy derivatives of various anthracyclinones show a high activity against P 388 mouse leukemia in certain in-vivo tests. A compound like 98 has been prepared in the 2-deoxy-2-iodo-a-L-ma no-series by Horton et al. [59, 60] starting from di-O-acetyl-L-rhamnal (28). Similarly, Thiem et al. have also successfully prepared the tetracenomycinone-C glycoside 99 [61]. From 4-0-acetyl-3-0-(p-methoxy)-benzyl-L-fucal (102) the glycoside derivatives 103 and 104 in the talo-series were obtained. 

Manzamine A is an alkaloid that was shown to inhibit the growth of P-388 mouse leukemia cells. The synthesis of the tetracyclic substructure of this natural product was reported by D.J. Hart. For the construction of the perhydroisoquinoline moiety, he utilized the Keck radical allylation. This transformation was carried out under standard conditions, reacting a secondary alkyl iodide with allyltributyltin. 

Studies 47, 108) of the structure/activity relationships for several quassinoids have established some of the structural requirements for optimal antineoplastic activity, particularly in P-388 mouse leukemia. These requirements are principally the following (Chart 2) a) Ring A with... 

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