17 P-hydroxysteroid dehydrogenase

Wu L, Einstein M, Geissler WM, Chan HK, Elliston , Andersson S. Expression cloning and characterization of human 17 P-hydroxysteroid dehydrogenase type 2,... 

In the fields of allergy and respiration, examples include 2-oxo-3-aminoazepine derivatives which act as dual neurokinin (tachykinin) NK1/NK2 receptor probes for development of options for treatment of asthsma and other airway diseases <07BMCL890> and benzo[l, 5]diazepine derivatives as new non-steroidal inhibitors of 17-P-hydroxysteroid dehydrogenase, an enzyme associated with hormone-dependent and neuronal diseases <07JEIMC29>. 

Trilostane 3 (or 17)P-Hydroxysteroid dehydrogenase Breast cancer Human... 

Leenders, F., Tesdorpf, J.G., Markus, M., Engel, T, Seedorf, U. Adamski, J. (1996) J. Biol. Ghent. 271, 5438-5442. Porcine 80-kDa protein reveals intrinsic 17 p-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer acitivties. 

Adamski, J., Normand, T, Leenders, F, Monte, D., Begue, A., Stehelin, D, Jungblut, P.W. de Launoit, Y (1995) Biochem. J. 311, 437-43. Molecular cloning of a novel widely expressed human 80 kDa 17 P-hydroxysteroid dehydrogenase IV. 

Leenders, F, Prescher, G, Dolez, V., Begue, A., de Launoit, Y. Adamski, J. (19%) Genomics yi, 403-404. Assignment of human 17 p-hydroxysteroid dehydrogenase IV to ehromosome 5q2 by fluorescence in situ hybridization. 

Fig. 3. Gonadal steroid biosynthetic pathway and the catalytic enzymes 1) cytochrome P-450scc 2) -hydroxysteroid dehydrogenase 3) 17a-hydroxylase (P-450scc17) 4) 17,20-desmolase or 17,20-lyase 5) 17(3-hydroxysteroid dehydrogenase 6) 5a-reductase and 7) P-450 aromatase.

Kokko L, Jaakohuhta S, Lindroos P et al (2006) Improved homogeneous proximity-based screening assay of potential inhibitors of 17 beta-hydroxysteroid dehydrogenases. Assay Drug Dev Tech 4 671-678... 

Monoester 4-(methoxycarbonyl)bicyclo[2.2.1]heptane-l-carboxylic acid 59 (Figure 4.17) is a building block of many potential therapeutic candidates for inhibitors of 11-p-hydroxysteroid dehydrogenase type 1 enzyme and their use in the treatment of non-insulin-dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and CNS disorders. It is also required for the synthesis of 5-hydroxytryptamine receptor agonists, useful for the treatment of anxiety disorders and schizophrenia [90,91]. 

Aldosterone is produced exclusively by the zona glomerulosa and is primarily controlled by the renin-angiotensin system (p. 1.5). The metabolic pathway for the synthesis of aldosterone has many of the same enzymes involved in cortisol biosynthesis. The glomerular z.one lacks the 17-hydroxylase enzyme and has the additional 18-hydroxylase and 18-hydroxysteroid dehydrogenase enzymes necessary for aldosterone synthesis. 

This enzyme [EC 1.1.1.50], also referred to as hydroxy-prostaglandin dehydrogenase, catalyzes the reaction of androsterone with NAD(P)+ to produce 5a-androstane-3,17-dione and NAD(P)H. Other 3a-hydroxysteroids can act as substrates as well as 9-, 11- and 15-hydroxy-prostaglandins. The stereochemistry is B-specific with respect to the pyridine coenzymes. 

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