3- beta-hydroxysteroid dehydrogenase

Simonian MH. ACTH and thyroid hormone regulation of 3 beta-hydroxysteroid dehydrogenase activity in human fetal adrenocortical cells. J Steroid Biochem 1986 25(6) 1001-6. [Pg.98]

G-12) (H-13) 3-beta-hydroxysteroid dehydrogenase deflciency. There is a decrease in mineralocorticoid and glucocorticoid production, and abnormal sexual development. [Pg.53]

Pang S. Congenital adrenal hyperplasia owing to 3 beta-hydroxysteroid dehydrogenase deficiency. Endocrinol Metab Clin North Am 2001 30 81-99, vi-vii. [Pg.2147]

Pang SY, Lerner AJ, Stoner E, Levine LS, Oberfield SE, Engel I, et al. Late-onset adrenal steroid 3 beta-hydroxysteroid dehydrogenase deficiency. I. A cause of hirsutism in pubertal and postpubertal women. [Pg.2147]

P26150 3 beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 3 41,900 20 1.0000 8 4... [Pg.14]

Buur A, N Mprk. (1992). Metabolism of testosterone during in vitro transport across Caco-2 cell monolayers Evidence for beta-hydroxysteroid dehydrogenase activity in differentiated Caco-2 cells. Pharm Res 9 1290-1294. [Pg.329]

Hilhorst, R., Spruijt, R., Laane, C., and Veeger, C. (1984). Rules for the regulation of enzyme-activity in reversed micelles as illustrated by the conversion of apolar steroids by 20-beta-hydroxysteroid dehydrogenase. Eur. J. Biochem., 144, 459-66. [Pg.281]

M8. Michael, A. E., Gregory, L., Piercy, E. C., Walker, S. M., Shaw, R. W., and Cooke, B. A., Ovarian 11 beta-hydroxysteroid dehydrogenase activity is inversely related to the outcome of in vitro fertilization-embryo transfer treatment cycles. Fertil. Steril. 64,590-598 (1995). [Pg.326]

Black cohosh 2. Geum chiloense 3. Liquorice 1. Cisplatin 2. Azathioprine 3. Cidosporin 4. Prednisolone t cytotoxic properties. Geum t plasma cidosporin levels 6-8-fold Unknown mechanism (black cohosh) Inhibits metabolizing enzymes. Glycyrrhizin present in liquorice inhibits the metabolizing enzyme of prednisolone, 11 beta-hydroxysteroid dehydrogenase, which converts the active metabolite to an inactive form. i clearance of prednisolone in healthy individuals Be aware. Advice is to avoid echinacea with immunosuppressants... [Pg.748]

The active ingredients of licorice inhibit the breakdown of mineralocorticoids by inhibiting 11-beta-hydroxysteroid dehydrogenase type 2, and its adverse effects relate mainly to mineralocorticoid excess, with sodium retention, potassium loss, and inhibition of the renin-angiotensin-aldosterone system (36). [Pg.1314]

In two cases prolonged intake of relatively small amounts of licorice resulted in hypertension, encephalopathy, and pseudohyperaldosteronism (37). Both patients were highly susceptible to the adverse effects of glycyrrhizinic acid because of 11-beta-hydroxysteroid dehydrogenase deficiency. [Pg.1314]

Palermo M, Shackleton CH, Mantero F, Stewart PM. Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrmol 1996 45 605-11. [Pg.2048]

Xpll.2 3.12 HSD17B10 Hydroxysteroid (17-beta) dehydrogenase 10 300256 17-Beta-hydroxysteroid dehydrogenase X deficiency, 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency, mental retardation... [Pg.359]

Wang, Y. and W. Ge. Cloning of zebrafish ovarian carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. Gen. Comp. Endocrinol. 127 209-216, 2002. [Pg.41]

Chrousos, G. P. Is 11-beta-hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions Proc. Natl. Acad. Sci. USA 2004, 101, 6329-6330. [Pg.209]

Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CHL, Edwards CRW. Mineralocorticoid acitivity of liquorice 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1987 ii 821—3. [Pg.302]

Arai, N., Masuzaki, H., Tanaka, T., Ishii, T., Yasue, S., Kobayashi, N., Tomita, T., Noguchi, M., Kusakabe, T., Fujikura, J., Ebihara, K., Hirata, M., Hosoda, K., Hayashi, T., Sawai, H., Minokoshi, Y., and Nakao, K. (2007). Ceramide and Adenosine 5 -Monophosphate-Activated Protein Kinase Are Two Novel Regulators of 1 l beta -Hydroxysteroid Dehydrogenase Type 1 Expression and Activity in Cultured Preadipocytes. Endocrinology 148, 5268-5277. [Pg.404]

Ghosh, D., Weeks, CM., Grochulski, P., Duax, W.L., Erman, M., Rimsay, R.L. Orr, J.C. (1991) Proc. Natl. Acad. Sci. USA. 88, 10064-10068. Three-dimensional structure of holo 3 alpha, 20 beta-hydroxysteroid dehydrogenase a member of a short-chain dehydrogenase family. [Pg.144]

Leenders, F., Tesdorpf, J.G., Markus, M., Engel, T., Seedorf, U. Adamski, J. (1996) J. Biol Chem. 271, 5438-5442. Porcine 80-kDa protein reveals intrinsic 17 beta-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities. [Pg.296]

Kokko L, Jaakohuhta S, Lindroos P et al (2006) Improved homogeneous proximity-based screening assay of potential inhibitors of 17 beta-hydroxysteroid dehydrogenases. Assay Drug Dev Tech 4 671-678... [Pg.112]

Morton NM, Holmes MC, FievetC, Staels B, Tailleux A, Mullins JJ, SecM JR (2001) Improved lipid and lipoprotein profile, hepatic insulin sensitivity and glucose tolerance in 11 beta-hydroxysteroid dehydrogenase type 1 null mice. J Bio Chtan 276(44) 41293-41300... [Pg.3824]

Sato T et al (1999) Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells Irom balding scalp. J Dermatol Sci 19(2) 123-125... [Pg.139]

Weuster-Botz, D., et al., March 2014. Novel 7 beta-hydroxysteroid dehydrogenase mutants and process for the preparation of msodeoxycholic acid. US patent 20140087421. [Pg.452]

Iq32-q41 48.77 HSD11B1 Hydroxysteroid (11-beta) dehydrogenase 1 600713 Cortisone reductase deficiency 2, obesity, insulin resistance... [Pg.333]

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