P-D-glucuronides

Dutton, G.J. and tiling, H.P.A. (1972) Mechanism of biosynthesis of thio-p-D-glucuronides and thio-p-D-glucosides. 

Drugs and drug-adjuvants p-D-glucuronides (Novartis Pfear 1999). Biotransftjrmation of FK-506 (Merck, Rahway, NJ Chen 1999) and synthetic CGP 62706 (Novartis). 

Pfaar, U. Gygax, D. Gertsch, W. Winkler, T. Ghisalba, O. (1999) Enzymatic synthesis of p-D-glucuronides in an enzyme membrane reactor. Chimia, 53, 590-3. 

Shirai, M., Moon, J.H., Tsushida, T., and Terao, J., Inhibitory effect of a quercetin metabolite, quercetin 3-0-p-D-glucuronide, on lipid peroxidation in liposomal membranes, J. Agric. Food Chem., 49, 5602, 2001. 

N.A. 3-O-P-D-glucuronide, mucilage, tannins, flavones.103117 Treat skin irritation and bums, infused flower for gargle for sore throat and laryngitis. It is anti-irritant and used as a mild sun screen, inhibiting microbial growth. 

Morphine and morphine 3-p-D-glucuronide were separated on two different 4.6-mm-diameter X 50-mm-long columns with 3-p.m particles.29 Column A was Cl8-silica run at 1.4 mL/min and column B was bare silica run at 2.0 mL/min. 

Coumarins also have a C6-C3 skeleton, but they possess an oxygen heterocycle as part of the C3-unit. There are numerous coumarins, many of which play a role in disease and pest resistance, as well as UV-tolerance. The coumarin umbelliferone (1.21) is popular in enzyme assays. Umbelliferone esters can be used as a substrate for non-specific esterase enzyme assays and in fluorescent immunoassays (Jacks and Kircher, 1967). In order to quantify the enzyme activity of the popular reporter gene P-glucuronidase (GUS), plant extracts can be incubated with 4-methylumbelliferyl P-D-glucuronide (4-MUG 1.22), which upon hydrolysis... 

Day et al. [2001] detected >20 species of metabolites, including quercetin 3-O-p-D-glucuronide (Q3GA), quercetin 3 -0-(3-D-glucuronide (Q3 GA), quercetin... 

Mottino AD, Cao J, Veggi LM, et al. Altered localization and activity of canalicular Mrp2b in estradiol-17-P-D-glucuronide-induced cholestasis. Hepatology 2002 35 1409-1419. 

Chemotaxis experiments (see Note 2) Use blind well Boyden chambers, that contain a volume of 100 pL in the lower compartment (Costar, Bodenheim, Germany). As filters use selfpunched (7 pm punch) polyvinylpyrrolidone containing polycarbonate filters (pore size 3 mm, Costar), which prior to use need to be washed with 1 M NaOH in 50 % (v/v) aqueous ethanol for 7 min followed by three washes in water (see Note 3). Use p-nitrophenyl-p-D-glucuronide (Sigma) at 10 mM in 0.1 M aqueous sodium acetate, pH 4.0, for p-glucuronidase detection (see Note 4). 

Fig. 4 Formation of uridine diphosphate glucuronic acid (UDP-GA) and its conjugation with clofibric acid. Inversion takes place during conjugation, the a-D-glucuronic acid forming a P-D-glucuronide. At a more alkaline pH, such glu-curonides may undergo intramolecular rearrangement to forms resistant to enzymic hydrolysis by P-glucuronidase.

COPD chronic obstructive pulmonary disease E217 p G estradiol-17 p -D-glucuronide... 

Dayal, B. and Salen G. FAB-MS and Proton NMR analysis of 5P-cholestane-3a,7a, 12a,24R,25-pentoI-3-0-P-D glucuronide. 

KH Dudley. Commentary stereochemical formulas of (P-D-glucuronides. Drug Metab Dispos 13(5) 524—526, 1985. 

Bromo-4-Chloro-3-Indolyl-P-D-glucuronide Agar (BCIG) 0157... 

Rate laws, however, can only establish the composition of the ratedetermining transition state, not its structure, and in particular they cannot distinguish between tautomers. 2 -Naphthyl p-D-glucuronide has a similar rate law to salicyl (3-glucoside, but the molecular events giving rise to it are different (Figure 3.17). If feg is the rate constant for the pH-independent part of the... 

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