Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

P53 +/- knockout mouse

The use of genetically engineered animals has the potential to supplant some of the traditional long-term (2-year) rodent studies. Mouse models have been developed for use as mechanistic models in cancer research. Potential alternatives to the 2-year rodent oncogenicity bioassay include the p53 knockout mouse and the Tg.AC mouse. ... [Pg.1661]

Short- and medium-term assays in transgenic models as a basis to provide essential information about the predisposing factors to specific genetic alterations in carcinogenesis include the rat liver foci model, the XPA—/— and the p53+/— knockout mouse models, the Tg.AC and Tg.rasH2 transgenic mouse models, and Ihe neonatal... [Pg.382]

Storer RD, French JE, Haseman J, Hajian G, LeGrand EK, Long GG, Mixon LA, Ochoa L, Sagartz J, Soper KA (2001) p53+/- hemizygous knockout mouse overview of available data. Toxicologic Pathology 29 30-50 Tennant RW(1993) Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard. Mutation Research 286 111-118... [Pg.816]

StorerRD, French JE, HasemanJ, etal. p53+/-hemizygous knockout mouse Overview of available data. Toxicol Pathol. 2001 29S 30-50. [Pg.282]

R.J. Francis, C.W. Lo, Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation. Development 133 (2006) 3451-3460. [Pg.103]


See other pages where P53 +/- knockout mouse is mentioned: [Pg.2]    [Pg.2]    [Pg.815]    [Pg.815]    [Pg.815]    [Pg.821]    [Pg.821]    [Pg.821]    [Pg.1661]    [Pg.117]    [Pg.2]    [Pg.2]    [Pg.815]    [Pg.815]    [Pg.815]    [Pg.821]    [Pg.821]    [Pg.821]    [Pg.1661]    [Pg.117]    [Pg.125]    [Pg.58]    [Pg.267]    [Pg.121]    [Pg.1417]    [Pg.3155]    [Pg.145]    [Pg.388]    [Pg.280]    [Pg.261]    [Pg.815]   
See also in sourсe #XX -- [ Pg.815 ]




SEARCH



Knockout

Knockout mouse

P53

© 2024 chempedia.info