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P53 gene expression

Mutational inactivation of two additional important tumor suppressor genes, p53, located on chromosome 17p, and the DPC-4 (deleted in pancreatic cancer) gene, located on chromosome 18q, occur later during the adenoma-carcinoma sequence. " Normal p53 gene expression is important for Gi cell-cycle arrest to facilitate DNA repair during replication, and to induce apoptosis, an irreversible cell process resulting in cell death. Inactivation of p53 occurs in up to 75% of sporadic colorectal cancers. ... [Pg.2389]

Sun Y, Nakamura K, Hegamyer G, Dong Z, Colburn N. No point mutation of Haras or p53 genes expressed in preneoplastic-to- neoplastic progression as modeled in mouse JB6 cell variants. Mol Carcinog 1993 8 49-57. [Pg.249]

Soleas, G.J., Goldberg, D.M., Grass, L., Levesque, M., and Diamandis, E.P., Do wine polyphenols modulate p53 gene expression in human cancer cell lines Clin. Biochem., 34 (5), 415-420, 2001. [Pg.554]

Gene Expression Profiling Gene Discovery Pathways p53... [Pg.239]

Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, Perng RP (1996) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 56 206-209 Oberall F, Oberhuber H, Maly K, Zaknun J, Demuth L, Grunicke HH (1991) Hexade-cylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res 51 807-812... [Pg.92]


See other pages where P53 gene expression is mentioned: [Pg.351]    [Pg.53]    [Pg.92]    [Pg.252]    [Pg.46]    [Pg.58]    [Pg.351]    [Pg.53]    [Pg.92]    [Pg.252]    [Pg.46]    [Pg.58]    [Pg.977]    [Pg.23]    [Pg.107]    [Pg.7]    [Pg.333]    [Pg.339]    [Pg.340]    [Pg.267]    [Pg.345]    [Pg.85]    [Pg.240]    [Pg.80]    [Pg.1]    [Pg.121]    [Pg.210]    [Pg.210]    [Pg.227]    [Pg.254]    [Pg.264]    [Pg.406]    [Pg.441]    [Pg.275]    [Pg.56]    [Pg.275]    [Pg.126]    [Pg.127]    [Pg.235]    [Pg.299]    [Pg.14]    [Pg.242]    [Pg.331]    [Pg.351]    [Pg.351]    [Pg.352]    [Pg.353]    [Pg.353]    [Pg.354]    [Pg.97]    [Pg.219]   
See also in sourсe #XX -- [ Pg.213 ]




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