Oxytetracycline soluble salt

Another set of conditions in which suspensions are recommended include those drugs that are chemically unstable when in soluble form (they can easily hydrolyze this is the case of, for example, oxytetracycline calcium salts see Ref. 9), or in which large specific surface areas are required. Let us mention, for instance, antacid or absorbent compounds, or radiological contrasts (8). As already discussed (sec Table I), suspending media need not be alway.s aqueous hence suspensions can still be used even with drugs that can degrade in aqueous solution. For example, fenoxymethylpenicillin can be dispersed in coconut oil to be administered as an oral suspension (8). 

The tetracyclines are amphoteric antimicrobial agents that can form salts with bases or acids (see Chs 1 and 2). Oxytetracycline is a bitter, yellow, odorless crystalline powder. The base is slightly water soluble and the hydrochloride is readily water soluble and is typically administered to horses by slow i.v. injection. It is effective at 5.5 mg/kg once daily for 2 days or more in the treatment of B. equi but is unlikely to completely clear this infection. It is, therefore, used for premunition. Rapid i.v. injection may cause a precipitous drop in blood pressure and collapse owing to the effects of calcium chelation on the myocardium. Intramuscular injection causes objectionable local reactions in horses and should be avoided. Oral administration may be more... 

Drugs of the tetraeycline group are amphoteric, forming salts with both acids and bases. They are used as parent compounds (e.g., oxytetracycline dihydrate) or as salts (e.g., oxytetracycline hydrochloride). Their lipid solubilities range from moderate (oxytetracycline and chlortetracycline) to high (doxycycline and minocycline), so that they are able to traverse cell membranes moderately or readily. The former two drugs are natural tetracyclines, while the latter two are semi-synthetic. 

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