Oxytetracy cline

Fig. 20. Selective bonding of oxytetracy-cline by KRS-5p cation exchanger with different grain sizes 1) 90 pm, 2) 7 pm, i) 0.1 pm...

Pasi F, Palazzini E Assessment of efficacy and tolerance of rifaximin in the topical treatment of pyodermia Controlled study vs. oxytetracy-cline. Derm Exper (Rome) 1993 8 13-20. 

Oxytetracy cline] (naphthacene carboxamide) structure determined (1952) by... 

A fixed-combination ointment containing oxytetracy-cline and polymyxin B is available for topical ocular use (see Table 11-6). The Centers for Disease Control and Prevention recommends ophthalmic ointments containing a tetracycline or erythromycin as an effective alternative to silver nitrate for prophylaxis of gonococcal ophthalmia neonatorum. A major advantage of using an antibiotic ointment such as oxytetracycline-polymyxin B is that it does not canse the chemical conjunctivitis typically produced by silver nitrate. 

McCracken, R.J. Blanchflower, W.J. Haggan, S.A. Kennedy, D.G. Simultaneous determination of oxytetracy-cline, tetracycline and chlortetracycline in animal tissues using liquid-chromatography, postcolumn derivatization with aluminum, and fluorescence detection. Analyst 1995, 120, 1761-1766. 

Dowling, P.M. Russell, A.M. (2000) Pharmacokinetics of a long-acting oxytetracy-cline-polyethylene glycol formulation in horses. Journal of Veterinary Pharmacology and... 

Oxytetracy Cline Sulfur trioxide Hydrogen fluoride... 

Class III variants (formed at 0.1% of the frequency of class I) show increased resistance to oxytetracyciine, and elevated levels of both a brown pigment and oxytetracy-cline. The majority of these variants also show a reproducible large-scale DNA rearrangement, which probably included deletion and a low-level reiteration (three cw lour copies) of a DNA fragment. These class III mutants are relatively unstable it is not possible to maintain the enhanced level of antibiotic production. 

The possibility of incorporating the wide spectrum antibiotics chlortetracycline and oxytetracy-cline into fresh meat, fish and poultry, in order to delay spoilage, is still under investigation. 

The 7-chloro-derivative, the first of the group to be isolated (1948) is known as chlortetracy-cline. The 5-hydroxy-derivative is oxytetracy-dine. More recently introduced tetracyclines are 6-demethyl-7-chlorotetracycline and 5-hydroxy-6-deoxy-6-methyienetetracycline. 

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