Oxygen-Dependent and Xenobiotically Induced Gene Expression Pathways

7 Oxygen-Dependent and Xenobiotically Induced Gene Expression Pathways 

With regard to the function of HIF, its dimerization partner ARNT is also a dimerization partner for many other transcription factors, among them the aryl hydrocarbon receptor (AhR dioxin receptor). When it was observed that both the xenobiotically induced and hypoxic gene expression used the same dimerization partner, several studies investigated the possibility that one affected the other. While some studies have not been able to show interaction, several others have indicated interaction which may be cell type specific (Gradin et al., 1999 Gassmann et al., 1997 Chan et al., 1999 Nie et al., 2001). There may also be differences in which pathway is preferred (Hofer et al., 2004). In addition to the interaction between aryl hydrocarbon receptor and HIF pathways, studies have indicated an interaction with HIF-pathway and the pathway involved in the generation of diel rhythmicity (Chilov et al., 2001). 

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