Expression pathway

Key words Transcriptome, Gene expression, Pathways, Heat maps, Deconvolution, Gene set enrichment, Gene clustering... 

Oxygen-Dependent and Xenobiotically Induced Gene Expression Pathways... 

The Cancer Bioinformatics Infrastructure Objects (caBIO) [16] (http //ncicb.nci.nih. gov/core/caBIO) is the primary architecture for data integration at the National Cancer Institute (NCI). It is based on a data warehouse that is used to integrate several of the NCI data sources. The content of the caBIO data warehouse is refreshed approximately biweekly and consists of variety of National Institutes of Health datasets, including genomic, expression, pathway, and clinical trials data. 

Many of regulatory RNAs referred to as small nonmessenger RNAs (snmRNA) or noncoding RNAs (ncRNA) act to regulate gene expression pathways in one of two basic mechanisms ... 

Roy SW, Hudson AJ, Joseph J, Yee J, Russell AG. Numerous fragmented spliceosomal introns. AT-AC splicing, and an unusual dynein gene expression pathway in Giardia lamblia. Mol Biol Evol. 2012 29 43-9. 

In the last step of the gene expression pathway, genomic information encoded in messenger RNAs is translated into protein by a ribonucleoprotein called the ribosome. The prokaryotic ribosome (MW approximately 2.6 x 10 daltons) is about 2/3 RNA and 1/3 protein and consists of 2 subunits the larger of which is approximately twice the molecular weight of the smaller. The small subunit mediates the interaction between the mRNA codon and the tRNA anticodon, an interaction on which the fidelity of translation depends. The large subunit, which sediments at SOS in prokaryotes, includes the activity that catalyzes peptide bond formation - peptidyl transferase. 

---