Oximes synthesis with addition

Table IX shows that at 130°C in an autoclave (12 atm acetylene pressure, 30% KOH, oxime/DMSO ratio 1 15), the synthesis is completed in 3 hr, the yield of 2-methyl- 1-vinylpyrrole being increased up to 45% (run 4). The highest yield of 2-methyl-1-vinylpyrrole (54%) was achieved under atmospheric pressure (oxime/DMSO 1 10, 120-140°C, 21 hr) and with addition of 40% KOH in portions every 5-6 hr (run 6). If the KOH concentration is...

The chiral moiety of the nitrone can also be located at the carbon atom. Yokoyama et al. [50] used this approach in the asymmetric synthesis of spiro isoxazohdines (Scheme 10.21). The ribose-derived nitrone 62 is obtained from the corresponding oxime by Michael addition to methyl acrylate. With a second equivalent of methyl acrylate, the sugar nitrone 62 gave a single cycloadduct 63, which was converted into the corresponding pyrrolidine by reduction. 

The synthesis of many metal derivatives of complexing agents such as 8-hydroxyquinoline and salicylaldehyde oxime begins with aqueous solutions of metal ions e.g. sulfates, nitrates, etc.). Addition of the ligand and suitable control of pH allows either precipitation of the coordination compound or its extraction into nonprotic media for either qualitative determination or work up (Eqs 6.14 and 6.15 ). 

Miyabe and Naito revealed a synthesis of y-lactones through sequential radical reaction of acrylates bearing oxime functionality with alkyl radicals generated from iodoalkane and efliyl radical [62]. That is, addition reaction of isopropyl radical to acrylate moiety of substrate 86 and the following cyclization to oxime functionality produced the p-amino-y-butanolide 87 with good diastereoselectivitiy (Scheme 40). 

The addition of ( )-(3-trimcthylsilylallyl)boronate (10) to the racemic oxime 9 has been used in connection with a total synthesis of cannabisativine n. The results are congruent with the application of ( )-crotylboronatc as organometallic reagent9,, 0. The reaction is anti selective and generates the diastereomeric hydroxylamines 11 and 12, where 11 is converted to a tetrahydropyridine 13, a useful intermediate for the synthesis of cannabisativine11. 

Clerici and Porta reported that phenyl, acetyl and methyl radicals add to the Ca atom of the iminium ion, PhN+Me=CHMe, formed in situ by the titanium-catalyzed condensation of /V-methylanilinc with acetaldehyde to give PhNMeCHMePh, PhNMeCHMeAc, and PhNMeCHMe2 in 80% overall yield.83 Recently, Miyabe and co-workers studied the addition of various alkyl radicals to imine derivatives. Alkyl radicals generated from alkyl iodide and triethylborane were added to imine derivatives such as oxime ethers, hydrazones, and nitrones in an aqueous medium.84 The reaction also proceeds on solid support.85 A-sulfonylimines are also effective under such reaction conditions.86 Indium is also effective as the mediator (Eq. 11.49).87 A tandem radical addition-cyclization reaction of oxime ether and hydrazone was also developed (Eq. 11.50).88 Li and co-workers reported the synthesis of a-amino acid derivatives and amines via the addition of simple alkyl halides to imines and enamides mediated by zinc in water (Eq. 11.51).89 The zinc-mediated radical reaction of the hydrazone bearing a chiral camphorsultam provided the corresponding alkylated products with good diastereoselectivities that can be converted into enantiomerically pure a-amino acids (Eq. 11.52).90... 

The scope and efficiency of [4+2] cycloaddition reactions used for the synthesis of pyridines continue to improve. Recently, the collection of dienes participating in aza-Diels Alder reactions has expanded to include 3-phosphinyl-l-aza-l,3-butadienes, 3-azatrienes, and l,3-bis(trimethylsiloxy)buta-l, 3-dienes (1,3-bis silyl enol ethers), which form phosphorylated, vinyl-substituted, and 2-(arylsulfonyl)-4-hydroxypyridines, respectively <06T1095 06T7661 06S2551>. In addition, efforts to improve the synthetic efficiency have been notable, as illustrated with the use of microwave technology. As shown below, a synthesis of highly functionalized pyridine 14 from 3-siloxy-l-aza-1,3-butadiene 15 (conveniently prepared from p-keto oxime 16) and electron-deficient acetylenes utilizes microwave irradiation to reduce reaction times and improve yields <06T5454>. 

Depending on the nature of the substrates, selectivity could be completely reversed between the two isomeric products. For example, switching R1 group between Buc and Ph gave high yields of the first and second product structures, respectively. The authors noted that the reaction did not proceed if the imine contained an ortho-MeO group at R2 or if the imine was replaced with an aldehyde, oxime, or hydrazone. The catalytic cycle is initiated by C-H activation of the imine, that is, the formation of a five-membered metallocycle alkyne insertion affords the intermediate drawn in Scheme 69. It is noteworthy that this is the first report of catalytic synthesis of indene derivatives via a C-H insertion mechanism (C-H activation, insertion, intramolecular addition). 

The electrophile-induced cyclization of heteroatom nucleophiles onto an adjacent alkene function is a common strategy in heterocycle synthesis (319,320) and has been extended to electrophile-assisted nitrone generation (Scheme 1.62). The formation of a cyclic cationic species 296 from the reaction of an electrophile (E ), such as a halogen, with an alkene is well known and can be used to N-alkylate an oxime and so generate a nitrone (297). Thus, electrophile-promoted oxime-alkene reactions can occur at room temperature rather than under thermolysis as is common with 1,3-APT reactions. The induction of the addition of oximes to alkenes has been performed in an intramolecular sense with A-bromosuccinimide (NBS) (321-323), A-iodosuccinimide (NIS) (321), h (321,322), and ICl (321) for subsequent cycloaddition reactions of the cyclic nitrones with alkenes and alkynes. 

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