Oxidative stress cosmetic products

Studies carried out with complete cells in vivo, cell membranes and other cell fractions point to the selective oxidation of phosphatidylserine (26) to a hydroperoxide (PS-OOH) on oxidative stress caused by toxic agents such as H2O2, t-BuOOH and cumyl hydroperoxide (27). Formation of PS-OOH is observed during apoptosis. These phenomena are important because of the cytotoxic effects of various peroxides used in commercial products coming into direct contact with the human body, as is the case of epidermal keratinocytes in contact with cosmetic formulations" ". The toxic effects of f-BuOOH are associated with vasoconstriction and damage to the vascular smooth muscles ". Global determination methods for primary lipid oxidation products are discussed in Section IV.B. 

Cyclic voltammetry proved to be a convenient method to reveal the oxido-reduction properties of the skin and of dermo-cosmetic creams. On the one hand, using microelectrodes, it was for the first time possible to evaluate the antioxidant properties on the skin surface. This simple protocol allowed to study in real time the global oxido-reductive state and to determine several antioxidant species. On the other hand, results showed the effect of oxidative stress on the evolution of the antioxidant properties of dermo-cosmetic products in time. 

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