Oxidative damage extracts

Siddique MS, Eddeb F, Mantle D and Mendelow AD (2000). Extracts of Ginkgo biloba and Panax ginseng protect brain proteins from free radical induced oxidative damage in vitro. 

Zitiianova and others (2006) examined the inhibitory effect of extracts from different kinds of fruits and vegetables on the oxidative damage to proteins in vitro. Dragsted and others (2004) investigated the relative influence of nutritive and nonnutritive factors in fruit and vegetables on oxidative damage and enzymatic defense. Jacob and others... 

CS160 Riso, P., D. Erba, F. Criscuoli and G. Testolin. Effect of green tea extract on DNA repair and oxidative damage due to H2O2 in Jurkat T cells. Nutrition Research 2002 22(10) 1143-1150. 

Singh, N., Rajini, P. S. (2008). Antioxidant-mediated protective effect of potato peel extract in erythrocytes against oxidative damage. Chemico-Biological Interaction, 173(2), 97-104. 

Kaviarasan, S., Vijayalakshmi, K., and Anuradha, C.V., 2004, Polyphenol-rich extract of fenugreek seeds protect erythrocytes from oxidative damage, Plant Foods Hum. Nutrition 59 143-147. 

Parihar M. S. and Hemnani T. (2004). Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus. J. Neural Transm. 111 1—12. 

In vitro studies have demonstrated that. vera latex derived anthraquinones in presence to ultraviolet light A (UVA) exhibited significant photo-oxidative damage to both cellular RNA and DNA 61). Several studies on photostability and phototoxicity of A vera extracts indicate that in presence of UV light it can generate the formation of free radicals 62, 63). 

The use of natural antioxidants in supplements can also exhibit pro-oxidant activity under certain conditions such as the concentration and nature of the polyphenolic compounds causing oxidative damage to important cellular components (48). Aqueous extracts and erode polyphenolic fractions of both traditional and green rooibos were evaluated for possible pro-oxidant activity using a Fenton reaction model system containing FeCb-EDTA and H2O2 for the generation of hydroxyl radicals. Pro-oxidant activity was shown for pure aspalathin while the dihydrochalcone and flavonoid contents of the enriched... 

In a model of oxidative damage of human red blood cells initiated by cumene hydroperoxide, Gawlik and Czajka" showed that white tea extracts at a level of 4 g/150 ml water significantly decreased the formation of the oxidation product, malo-ndialdehyde. White tea extract also showed a superior reducing activity compared to other plant extracts, such as wheat sprouts, Morinda citrifolia, and fermented papaya. ... 

Figure 17-6 Proposed model for redox-dependent activity of the Fe-Zn and Fe-Fe forms of calcineurin. Native calcineurin isolated from bovine brain contains a dinuclear Fe +-Zn + cluster which is catalytically active. The presence of Zn + in the M2 site precludes further oxidation of the cluster, a property which may prevent oxidative damage to this form of the enzyme. Reduction of the Fe ion by one electron produces the inactive Fe +-Zn + cluster [14]. Calcineurin can also be assembled to contain a dinuclear iron center. Three oxidation states are accessible in this form, of which only the mixed valence oxidation state is catalytically active [35]. The dependence of the activity on the redox state of the Fe-Fe center of calcineurin parallels observations made of calcineurin activity in crude brain extract [48].

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