Ovulation inhibition, contraceptive method

A crossover study in 12 subjects found that sibutramine 15 mg daily, given for 8 weeks, had no clinically significant effect on the inhibition of ovulation caused by an oral contraceptive, and it was concluded that there is no need to use alternative contraceptive methods while taking sibutramine. ... 

Contraception is the prevention of pregnancy following sexual intercourse by inhibiting sperm from reaching a mature ovum (i.e., methods that act as barriers or prevent ovulation) or by preventing a fertilized ovum from implanting in the endometrium (i.e., mechanisms that create an unfavorable uterine environment). 

Currently, the most effective method to prevent conception is by oral steroid hormone treatment (Figure 34-9) to inhibit or modify the cyclic changes in endogenous reproductive hormones. Two effective types of oral contraceptives are used with proven success one to prevent ovulation, the other to prevent implantation. 

Although gestrinone, at the dose used for endometriosis, can inhibit ovulation, it is not sufficiently reliable to be used as a contraceptive. The manufacturer strongly emphasises the importance of using a b er method of contraception while taking gestrinone because they say that not only are... 

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