Ovitrelle

Hormones Gonal F, Luveris, Ovitrelle/Ovidrel, Puregon/ Follistim, Thyrogen... 

Ovitrelle (rhCG) Serono Used in selected assisted reproductive techniques... 

Ovitrelle (tradename in EU, sold as Ovidrel in the USA and also known as choriogonadotropin alfa) is a recombinant hCG approved for general medical use in the EU and USA in 2001. It is indicated for the treatment of female infertility due to anovulation and for patients undergoing assisted reproductive technology. It is used to trigger final follicle maturation and luteinization after follicle stimulation. 

Two of the more recent such approvals are that of Ovitrelle and Luveris. Ovitrelle is the trade name given by Serono to its recombinant hCG-based product. The producer is an engineered CHO cell line that has been co-transfected with the genes coding for both the hCG a- and P-subunits. Downstream processing entails a combination of several chromatographic and ultrafiltration steps and the final product is presented in freeze-dried form. Each vial of product contains 285 fig of active substance (hCG) and the product has been assigned a 2 year shelf-life. It is reconstituted with water for injections (WFI) immediately before use. 

The recombinant forms of these proteins (Gonal-f , Luveris , Ovitrelle, and Puregon ), produced in CHO cells, are indicated for treating female infertility (Table 16.1). 

Ovitrel le /Ovidrel/ Choriogonadotropin a Gonadotropin Female infertility... 

Ovitrelle (also termed Ovidrelle rhCG produced in CHO cells) Serono used in selected assisted reproductive techniques 2001 (EU), 2000 (US)... 

Italy choriogonadotropin alfa peptide Ovidrel Ovidrelle, Ovitrelle Recombinant human choriogonadotropin expressed in CHO cells Hormone... 

Overall dyskinesia rating scale 339 Overall glycemic control 1457 Ovidrel (Ovitrelle) 477 Ovitrel 15 Oxalis tuberose 483... 

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