Other compounds with fungicidal properties

Active substances with fungicidal properties belonging to various groups of compounds are summarised in this chapter. One part of the compounds is only of theoretical importance and has not been used in agriculture for plant protection. The group comprises also new experimental active substances, which are not yet fully known, but seem to be promising. 

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The other substituent on the nitrogen atom also affects activity. However, one or more chlorine atoms introduced into the methyl group do not influence substantially the fungicidal properties of the compound. Active substances with excellent fungicidal action can obtained in the group of sulfamides. 

Triphenyl- and tributyltin compounds have strongly biocidal properties and are employed in some agricultural fungicides and wood preservatives42. Other possible applications include disinfectants for use in hospitals and for the eradication of snails that transmit bilharzia. However, these compounds are potentially hazardous because of the ease with which they inhibit oxidative phosphorylation in man. Oral administration of diethyltin diiodide as a treatment for boils led to many deaths43. ... 

Selectivity is brilliantly displayed by a multiplicity of compounds developed for the control of powdery mildews. For 148 years from 1803 until 1951 sulfur was the only significant fungicide for powdery mildew. In 1949 a new fungicide appeared with the publication of 6-(1-methylheptyl)-2,4 dinitro-phenyl crotonate (8). Two years later Yarwood reported (9) its anti-powdery mildew properties. It went on to worldwide usage and thus stimulated a vast search for others. Now we have many effective compounds, including benomyl, binapacryl, dodemorph, folpet, parinol, piperalin, pyrazophos, thiophanate, tridemorph, triforine, and dthers. 

Other 1,2,4-triazole containing tertiary alcohols are being developed as fungicides, and it is likely that further compounds from this family, with useful biological properties, will be discovered. 

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