Osteoarthritis cartilage destruction

The most well characterized of the p38 kinases, the final MAPK phosphorelay pathway, is p38a, which is expressed by most cells and regulates the expression of many cytokines. Interleukin 1, IL-1, a product of inflammatory cells, has been implicated in modulating the response to mechanical loading in a number of tissues. IL-1 is a product of inflammatory cells thought to be involved in cartilage destruction in osteoarthritis and in bone resorption associated with total joint implant failure. 

Kanbe K, Takemura T, Takeuchi K, Chen Q, Takagishi K, Inoue K. Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis. J Bone Joint Surg Br 2004 86(2) 296-300. 

These OTC medications are recommended to clients with osteoarthritis to help build up and reduce the destruction of cartilage in the joints. 

Osteoarthritis A chronic disease involving the joint, especially those bearing the weight, characterized by destruction of articular cartilage, overgrown of bone with impaired function. 

Furey, M. J. Biochemical aspects of synovial joint lubrication and cartilage wear, European Society of Osteoarthrology. Symposium on Joint Destruction in Arthritis and Osteoarthritis, Noordwijkerhout, The Netherlands, May 24-27,1992. 

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