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Organophosphorus reproductive effects

Ryan LC, Endecott BR, Hanneman GD, et al. 1970. Effects of an organophosphorus pesticide on reproduction in the rat. Department of Transportation, Federal Aviation Administration, Office of Aviation Medicine, AD 709327. [Pg.194]

As with most organophosphorus insecticides, acute toxicity is predominant. However tolerance to repeated exposures can occur. The no-observed-adverse-effect level (NOAEL) established from a rabbit developmental toxicity study was 50 mg kg day based on maternal toxicity (i.e., reduced body weight gain). Developmental toxicity studies were negative in rats and rabbits. A two-generation reproductive toxicity study in rats showed no increased sensitivity in pups compared to dams. Repeated exposure to malathion does not cause delayed neurotoxicity. The NOAEL of 2.4 mg kg day was established based on plasma cholinesterase inhibition in a long-term dosing study in rats. [Pg.1588]

See other pages where Organophosphorus reproductive effects is mentioned: [Pg.2]    [Pg.896]    [Pg.1080]    [Pg.1080]    [Pg.134]    [Pg.109]    [Pg.74]    [Pg.3]    [Pg.134]    [Pg.233]    [Pg.288]   
See also in sourсe #XX -- [ Pg.387 , Pg.388 ]



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ORGANOPHOSPHORUS

Reproduction, Effects

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