Organon International

Roger M. Finder, Organon International, Oss, The Netherlands Antipsychotic Agents and Dopamine Agonists 12... 

Detector F ex 385 em 452 following post-column extraction. The column effluent mixed with dichloroethane pumped at 1 mL/min and the mixture flowed through a 1 m x 0.25 mm ID stainless steel coil to a phase separator (Organon International) and then the organic phase flowed through the detector (J.Chromatogr. 1987, 421, 327 Anal.Chim.Acta 1987,192, 267). 

J. Vink, J.J. de Ridder, C.J. Timmer and H. de Nijs Organon International B.V., Scientific Development Group Oss, Netherlands... 

AKZO Pharma Division of Organon International B.V. also reported how TBA concentrations affect the stability of freeze-dried sucrose formulations. Adding 5 percent TBA to a 180mg/ml sucrose solution resulted in a pharmaceutically acceptable, stable freeze-dried cake with no collapse. Therefore, while TBA addition did not change the collapse temperature of the sucrose solution, it increased the rate of sublimation. The increase thereby prevented the product from ever rising to the collapse temperature. 

Bovine serum albumin (BSA) and human serum albumin (HSA) were provided by Pierce (Rockford, Illinois, U.S.A.). Peroxidase-labeled anti-mouse IgG was provided from Organon Teknika Cappel Products (West Chester, Pennsylvania, U.S.A.). Polyvinyhdene difluoride (PVDF) membranes (Immobilon-N) were purchased from MiUipore Corporation (Bedford, Massachusetts, U.SA.). A glass microfiber filter sheet (GF/A) was purchased from Whatman International Ltd. (Maidstone, U.K.). All other chemicals were standard commercial products of analytical grade. 

Internal standard l-(3o , 17/3-dihydroxy-2/S-morpholino-5o -androstan- 16/3-yl)- 1-meth-ylpiperidinium bromide (Org 7402, Organon) (21)... 

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