Organic ionic liquids multicomponent reactions

The use of ionic liquids in numerous organic transformations ranging from one-step to one-pot multicomponent reactions had been documented in the literature. In this account, we will provide a brief overview of some of the recent advancements in this area and depict that ionic liquids are indeed versatUe green solvents in organic synthesis. 

Chapter 12 illustrates the apphcability of ionic hquids in multicomponent reactions and confirms the usefulness of ionic liquids as substituents of traditional organic solvents in certain synthetic transformations. 

A powerful tool to synthesize easily minute amounts of organic compounds on demand by using both ionic liquids droplets as microreactors and electrowetting as a fluidic motor has been described. These droplets can be moved, divided and combined on an open digital microfluidic lab-on-a-chip system [60]. This has been demonstrated with BTS ILs used as reaction media and supports, properly functionalized to perform the Grieco s multicomponent synthesis of tetrahydroquinolines (Fig. 5.5-3). It is assumed that this original concept should impact many areas, notably combinatorial chemistry, parallel synthesis, optimization of protocols, synthesis of dangerous products and embedded chemistry in a portable device. 

Abstract Some innovative S3mthetic methods in organic chemistry are concisely presented, multicomponent reactions, specifically the Ugi multicomponent reaction, parallel syntheses and combinatorial chemistry, mechanochemically promoted organic reactions, organic reactions promoted by microwave irradiation and syntheses in ionic liquids. Examples of chemoselective or as3mimetric syntheses completed by one of the presented specific methods are presented for the antihy-pertensive drug nifedipine, the alkaloid tropinone, the local anesthetic xylocaine and the HIV inhibitor tipranavir. 

Chemical Description. The constituents of the system include atoms, ions, molecules as well as molecular and nonmolecular solids. The homogeneous catalytic reaction of interest occurs in the multicomponent liquid phase Pl- By definition, all the molecular and ionic species S involved directly in the catalysis are soluble in this liquid phase. In particular, one or more organic reagents must be present in Pl- The liquid phase must contain numerous soluble transition-metal... 

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