Organ distal

Salmonella are motile, non-lactose-fermenting, gram-negative bacilli. In salmonellosis, the organisms penetrate the epithelial lining to the lamina propia with production of diffuse inflammation. The distal ileum and colon are sites of infection. 

The gastrointestinal microflora provide another potential site for drug metabolism within the GIT, and it has received some attention. In normal subjects the stomach and proximal small intestine contain small numbers of microorganisms. Concentrations of these organisms increase toward the distal end of the intestine. A wide variety of aerobic and anaerobic organisms are present in the gut. The microflora, derived primarily... 

The spatial organization of the cell bodies of the motor neurons follows a proximal-distal rule. Motor neurons that innervate the most proximal muscles (axial muscles of the neck and trunk) lie most medially in the gray matter. Motor neurons innervating the most distal muscles (wrists, ankles, digits) lie most laterally in the gray matter. 

More simply, in the early regions of the tubule (proximal tubule and Loop of Henle), Na+ ions leave the lumen and enter the tubular epithelial cells by way of passive facilitated transport mechanisms. The diffusion of Na+ ions is coupled with organic molecules or with other ions that electrically balance the flux of these positively charged ions. In the latter regions of the tubule (distal tubule and collecting duct), Na+ ions diffuse into the epithelial cells through Na+ channels. 

The organization of MTs in neurons differs several ways from that seen in non-neuronal cells (Fig. 8-3) [9]. Axonal and dendritic MTs are not continuous back to the cell body nor are they associated with any visible MTOC. Axonal MTs can be more than 100 pm long, but they have uniform polarity, with all plus-ends distal to the cell body. Dendritic MTs are typically shorter and often exhibit mixed polarity, with only about 50% oriented plus-end distal. Recent work suggests that MTs in both axons and dendrites are nucleated normally at the MTOC, but they are then released from the MTOC and delivered to neurites [10],... 

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