Orexin actions

Bayer, L., Eggermann, E., Saint-Mleux, B. et al. (2002). Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons. J. Neurosci. 22, 7835-9. 

Espana, R. A., Baldo, B. A., Kelley, A. E. Berridge, C. W. (2001). Wake-promoting and sleep-suppressing actions of hypocretin (orexin) basal forebrain sites of action. Neuroscience 106, 699-715. 

As predicted, MCH l orexin mice displayed an intermediate body weight phenotype, indicating independent and opposing neuromodulatory actions of MCH and orexin on metabolism. Surprisingly, however, rather than expressing an attenuated narcoleptic phenotype, MCHr orexin l mice exhibited more severe behavioral state instability during the active phase. When compared with orexin mice, the double null mice had about twice as many cataplectic episodes (Fig. 15.7A), they were less able to maintain wakefulness, and... 

Tu B, Timofeeva O, Jiao Y et al (2005) Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. J Neurosci 25 1718-29 Ueda H, Fukushima N, Ge M et al (1987) Presynaptic opioid kappa-receptor and regulation of the release of Met-enkephalin in the rat brainstem. Neurosci Lett 81 309-13 van den Pol AN, Gao XB, Obrietan K et al (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 18 7962-71... 

---