Oral vaccination microcapsules

Oral targeting can be achieved using microspheres those less than 10 pm in diameter have been shown to target the Peyer s patch. " Microspheres less than 5 pm were shown to be transported through the lymphatics within macrophages and those larger than 5 pm remained in the Peyer s patch. " Toxoid vaccine microcapsules were effectively delivered and released in the gut-associated lymphoid tissue following oral administration. "... 

Live rotavirus vaccine was developed for oral delivery to prevent infections by the virus in young children. However, incorporation of live rotavirus into poly (oL-lactide-co-glycolide) microspheres or alginate microcapsules was reported to result in a significant loss of rotavirus infectivity. The loss was reduced by stabilization of the rotavirus vaccine with an excipient blend of cellulose, starch, sucrose, and gelatin at a mass ratio of 30 30 30 10 in granules or tablets. ... 

Thus, presently the emphasis is given to the development of mucosal (oral and nasal) vaccines in conjunction with microcapsulate systems. 

TIAN j, SUN X, CHEN X, YU J, Qu L, WANG L.The formulation and immunisation of oral poly(DL-lactide-co-glycolide) microcapsules containing a plasmid vaccine against lymphocystis disease virus in Japanese flounder Paralichthys olivaceus). Int Immunopharmacol 2008,8, 900-908. 

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