Oral solids preparation method

Low-substituted hydroxypropyl cellulose is widely used in oral solid-dosage forms. It is primarily used in tableting as a disintegrant, and as a binder in wet granulation. It has been used in the preparation of rapidly disintegrating tablets produced by direct compression methods. In addition, low-substituted hydroxypropyl cellulose has been used to delay the release of drug from a tablet matrix. ... 

An example of a simple CZE method for peptide analysis and characterization is the one developed for protegrin IB-367.37 IB-367 is a peptide containing 17 amino acid residues that possess antimicrobial properties, and it is being developed for treatment of oral mucositis associated with aggressive cancer chemotherapy as well as other topical applications. This polycationic product was chemically synthesized using solid-phase and purified by preparative reversed-phase HPLC. IB-367 is rich in cysteine and arginine residues. 

At first, combinatorial chemistry focused on peptide and nucleotide libraries synthesis, but because poor pharmacokinetical properties cause poor oral availability of this kind of molecule, there is increasing interest in the development of new methods to prepare small, drug-tike molecules which obey lipinski s mle of five [303]. Heterocyclic compounds can offer a high degree of structural diversity and have proven to be useful as therapeutic agents. For these, there are recent advances in the preparation of heterocycles on solid supports [304]. The examples reported in this section are organized by their ring size. 

This chapter discusses the formulation and methods of preparation of the most used solid dosage forms that can be prepared in hospital or community pharmacies. The formulation of licensed medicines, particularly tablets and capsules, is discussed to such an extent as it is necessary to understand how they are made in case they may have to be adapted for the preparation of other oral preparations in pharmacies. 

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