Hydroxypropyl Cellulose, Low-substituted

JP Low-substituted hydroxypropylcellulose USPNF Low-substituted hydroxypropyl cellulose 

The USPNF 23 describes low-substituted hydroxypropyl cellulose as a low-substituted hydroxypropyl ether of cellulose. When dried at 105°C for 1 hour, it contains not less than 5.0% and not more than 16.0% of hydroxypropoxy groups (—OCH2CHOHCH3). Low-substituted hydroxypropyl cellulose is commercially available in a number of different grades that have different particle sizes and substitution levels. 

Low-substituted hydroxypropyl cellulose is widely used in oral solid-dosage forms. It is primarily used in tableting as a disintegrant, and as a binder in wet granulation. It has been used in the preparation of rapidly disintegrating tablets produced by direct compression methods. In addition, low-substituted hydroxypropyl cellulose has been used to delay the release of drug from a tablet matrix.  

The typical content of low-substituted hydroxypropyl cellulose in a formulation is approximately 5-25%. 

Low-substituted hydroxypropyl cellulose occurs as a white to yellowish white powder or granules. It is odorless or has a slight, characteristic odor, and it is tasteless. 

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Hydroxyethyl cellulose hydroxypropyl cellulose, low-substituted hypromellose. 

Table II Typical properties of hydroxypropyl cellulose, low-substituted, for selected grades.

K.R Hapgood, S. Obara, Hydroxypropyl cellulose, low-substituted, in R.C. Rowe, P.J. Sheskey, M.E. Quinn, eds.. Handbook of Pharmaceutical Excipients, American Pharmaceutical Association and London Pharmaceutical Press, Washington, D.C., pp. 322-324, 2009. 

The use of hydroxypropyl cellulose (HPC), a binder, has increased in recent years [50a -50c], This material has been shown to reduce the incidence of capping when compared with MCC, PVP, and starch [50a], In addition, low substituted grades of HPC can also be used as a filler/ binder [50b]. 

Particle size and true density of spray-dried sodium salicylate were affected by binder excipients. Drug distribution in spray-dried tolbutamide particles was dependent on the disintegrant excipients used. The drug distributed throughout the particles with low-substituted hydroxypropyl cellulose as excipient but only deposited on the surface with pregelatinized corn starch. ° ... 

Excipient Low-substituted hydroxypropyl cellulose, type LH-11 Manufacturer Shin-Etsu Magnification 350x... 

Low-substituted hydroxypropyl cellulose is manufactured by reacting alkaline cellulose with propylene oxide at elevated temperature. Following the reaction, the product is recrystallized by neutralization, washed, and milled. 

Low-substituted hydroxypropyl cellulose is generally regarded as a nontoxic and nonirritant material. 

Low-substituted hydroxypropyl cellulose is a stable, though hygroscopic, material. The powder should be stored in a well-closed container. 

Shin-Etsu Chemical Co. Ltd. Technical literature L-HPC, low-substituted hydroxypropyl cellulose, 1991. 

Klcinebudde P. Shrinkage and swelling properties of pellets containing microcrysullinc cellulose and low substituted hydroxypropyl cellulose I. Shrinking properties. Int J Riarm 1994 109 209-19. 

Kawashima, Y., Takeuchi, H., Hino, T., Niwa, T., Lin, T. L., Sekigawa, F. and Ohya, M. The effects of particle size, degree of hydroxypropyl substitution and moisture content of low-substituted hydroxypropyl cellulose on the compactibility of acetaminophen and the drug release of the resultant tablets. S. T. P Pharma Sci. 3 170—177, 1993. 

Low substituted-hydroxypropyl cellulose By reacting alkafine cellulose with propylene oxide Binder, Disintegrant... 

Hydroxypropyl methylcellulose with microcrystalline cellulose and low substituted hydroxypropyl cellulose Herpetrione in SDS and PVP K-30 to form nanosuspension Solvent casting 1.13.14 [19]... 

Microcrystalline cellulose, Hydroxypropylmethyl cellulose, Polysorbate 80 and low-substituted Hydroxypropyl cellulose dexamethasone Coating Pharmacokinetic study [20]... 

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