Oral Administration of Vancomycin Solid-state Emulsion

Oral Administration of Vancomycin Solid-state Emulsion 

F nre 2. Serum concentrations of vancomycin in conscious rats following administration of vancomycin within W/O/W solid-state emulsion. A 50-mg/kg dose of a vancomycin solid-state emulsion formulation was orally administered to rats. Serum levels of vancomycin were measured immediately prior to administration (r = 0) and 0.5, 1,2,3,4, 5,6,8, 10, 12, 24, and 36hr after administratioiL Data represent the mean SEM obtained in 3 animals. Sensitivity limit of assay was 2.0pg/ml (95% confidence greater than zero). Rats orally admirtistered the eqiuvalent dose of the cotrtmereial oral product resulted in no detectable semm levels (data not shown). (After Shively and Thompson, 1995.) 

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