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Optical rotation formation

The ion-pair return phenomenon can also be demonstrated by comparing the rate of loss of enantiomeric purity of reactant with the rate of product formation. For a number of systems, including 1-aiylethyl tosylates, ftie rate of decrease of optical rotation is greater than the rate of product formation. This indicates the existence of an intermediate that can re-form racemic reactant. The solvent-separated ion pair is the most likely intermediate in the Winstein scheme to pl this role. [Pg.271]

The purest laevo-bornyl formate examined had a specific gravity 1 016, optical rotation — 48° 56, refractive index 1-47121, and boiling-point 97° at 15 mm. pressure. The ester has the constitution... [Pg.171]

Turpentine Oil.—This is readily recognised in oils which contain no pinene, as this is the main constituent of turpentine oil. It is usually found in the first distillates, and generally reduces the specific gravity and effects the solubility and optical rotation. Its presence is proved by the formation of pinene hydrochloride (melting-point 125°) and the nitro-sochloride (melting-point 103°). If pinene is a constituent of the oil itself, the addition of turpentine can only be proved by comparison with an authentic sample. [Pg.356]

The optical purities were determined solely from the optical rotations of the (/ -cyanohydrins thus obtained. Only for (/ )-a-hydroxybcnzeneacetonitrile, available from benzaldehyde, was an optical purity determined by comparison with the natural product. Variation of the reaction conditions (pH, temperature, concentration) in water/ethanol led to no appreciable improvementsl4. The use of organic solvents that are not miscible with water, but in which the enzyme-catalyzed reaction can still take place, resulted in suppression of the spontaneous addition to a significant extent, whereas the enzyme-catalyzed formation of cyanohydrins was only slightly slower (Figure l)13. [Pg.668]

The racemization of the phosphine (118) has been followed by optical rotation. The lack of a solvent effect indicates that there is little change in dipole moment in the formation of the planar transition state. Circular dichroism has been used to study the interactions of nucleotides with proteins and DNA with a histone. Faraday effects have been reviewed. Refraction studies on chloro-amino-phosphines, fluoro-amino-phosphines, and some chalcogenides are reported. [Pg.278]

Recently,14 the acid VIII (from the condensation of D-galactose with ethyl acetoacetate) was dehydrated by heating its aqueous solution, but no crystalline product was isolated. Nevertheless, the changes in the optical rotation of the sirup and its reaction with periodic acid indicated that anhydride formation had occurred. Up to the present, efforts to isolate the dialdehyde... [Pg.116]

Vigorous hydrolysis of neomycin results in the formation of furfural which may be quantitated in a number of different ways- 5 156. Dutcher et all57 use(j a UV spectrophotometric procedure, measuring the absorbance of the solution at 280nm. A similar procedure combined with measurement of the optical rotation has been used by Brooks et all58 to determine the neomycin B and C content... [Pg.433]

In the original paper, the authors performed the reaction using commercially available bakers yeast from a supermarket or bakery. Initially a trial run using similar quantities of Sigma dried yeast resulted in an extremely vigorous initial fermentation, so the quantity of dry yeast was reduced by factor of 5. The contributors assessed the enantiomeric excess of the alcohol by formation of the (+)-MTPA ester and examination of the 19F NMR spectrum. However, the value obtained for the optical rotation was consistent with that reported in the literature. [Pg.139]

We have thus eliminated ionization, polymerization, hydrate formation, 0-lactone formation and formation of d-malic acid from /-malic acid as playing important parts in the change of optical rotation of malic acid with concentration, though some or most of these may play a minor part. [Pg.2]

A rare case of asymmetric induction caused by isotopic substitution was observed (326) when optically active (+)-() )-a,a-dideuteriodi-benzyl sulfoxide 331 was chlorinated with dichloroiodobenzene in pyridine, a,a-Dideuteriobenzyl a -chlorobenzyl sulfoxide 332 was obtained as a major regioisomer with at least 78% isotopic purity. The high stereospecificity of the reaction is indicated by formation of essentially only one of the possible diastereomers. Oxidation of sulfoxide 332 affords the sulfone 334, which has high optical rotation. [Pg.456]

In this paper, we first briefly recall the main features of the collagen molecule, then we describe the structure of the gels, using different experimental techniques (optical rotation (O.R.), electron microscopy, proton nuclear magnetic resonance (N.M.R.)) for different thermal treatments. A phenomenological and a microscopic interpretation of the mechanisms of gel formation is suggested. [Pg.212]

The basic experiment consisted of simply treating an l-UNCA with a base and monitoring the formation of the d-UNCA. The most straightforward analysis is accomplished by polarimetry. For example, Boc-Phe-NCA was dissolved in THF at a concentration of 0.33 M, and 1.5 equivalents of TEA were added. The resulting solution was placed in a polarimeter cell and the optical rotation was monitored over time (Figure 1). [Pg.664]

The inherent difficulty in analyzing enantiomers arises from the well-known fact that apart from their chiroptical characteristics, optical isomers have identical physical and chemical properties in an achiral environment (assuming ideal conditions). Therefore, methods of distinguishing enantiomers must rely on either their chiroptical properties (optical rotation, optical rotatory dispersion, circular dichroism), or must employ a chiral environment via diastereomer formation or interaction. Recently, it has become increasingly clear that such diastereomeric relationships may already exist in nonracemic mixtures of enantiomers via self-association in the absence of a chiral auxiliary (see Section 3.1.4.7.). [Pg.147]


See other pages where Optical rotation formation is mentioned: [Pg.78]    [Pg.214]    [Pg.214]    [Pg.171]    [Pg.149]    [Pg.221]    [Pg.484]    [Pg.86]    [Pg.108]    [Pg.641]    [Pg.34]    [Pg.636]    [Pg.154]    [Pg.62]    [Pg.115]    [Pg.54]    [Pg.144]    [Pg.152]    [Pg.158]    [Pg.200]    [Pg.225]    [Pg.361]    [Pg.164]    [Pg.277]    [Pg.230]    [Pg.75]    [Pg.211]    [Pg.267]    [Pg.274]    [Pg.259]    [Pg.81]    [Pg.154]    [Pg.600]    [Pg.736]    [Pg.165]    [Pg.358]   
See also in sourсe #XX -- [ Pg.213 ]

See also in sourсe #XX -- [ Pg.21 , Pg.213 ]




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Optical rotation

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