Opsonic activity

Runyon BA Patients with deficient ascitic fluid opsonic activity are predisposed to spontaneous bacterial peritonitis. Hepatology... 

Runyon, B.A., Antillon, M.R., McHutchison, J.G. Diuresis increases ascitic fluid opsonic activity in patients who survive spontaneous bacterial peritonitis. J. Hepatol. 1992 14 249-252... 

Differences in opsonic activity occur between normal serum and serum from infected patients (Table 3). The infected serum produces the same diminished latency period on normal cells as on cells from infected subjects. Normal serum induces the same response either with normal or infected cells. The rates of O2 consumption and Oi production are slightly increased when the stimulation is initiated with serum from infected subjects this observation suggests that the efficiency of the opsonic activity determines the metabolic response of the cells. The ability of PMN to produce a normal respiratory burst depends upon both humoral and... 

Effect of Crossbeactinc Serum of Normal Controls and Infected Patients on Opsonic Activity, Oxygen Consumption, and Superoxide Radical Production ... 

Seth, V., and Chandra, R. K., Opsonic activity phagocytosis and bactericidal capacity of polymorphs in undernutrition. Arch. Dis. Child. 47, 282-284 (1972). 

OPSONIC ACTIVITY, FRESH vs FROZEN SERUM. FRESH vs... 

FIGURE 2, Compain,son of various types of sera relative to opsonic activity and baseline ahemi luminescence. PBMC SxlO /vial with M = 100 vl fresh serum, A = 100 vl frozen serum,Q = 100 frozen opsonized zymosan, 0 100 vi zymosan opsonized with frozen serum, 100 vl zymosan opsonized with fresh serum. 

Evidence for complement consumption in acute PEM has also been presented. Chandra (1975) has demonstrated significant immunocon-glutinin titers, an antibody to activated complement components, in acute PEM. Consistent with this observation, Chandra also found electrophoretically altered C3 in serum of such patients, and in some subjects anticomplementary activity capable of reducing the hemolytic complement titer through activation of the complement cascade. Haller et al. (1978) have also reported increased levels of C3D and reduced factor B, suggesting vivo activation of the alternative pathway. We have demonstrated diminished serum opsonic activity in acute PEM for IE. coli (Keusch et al., 1977a, b) particularly for a strain opsonized via the alternative pathway. 

Opsonic activity for E. coll strains opsonized via either pathway of complement activity was also moderately decreased. Considering the fact that hemolytic complement activity and opsonin levels to these organisms are equal to values found in control patients when acute PEM patients are fully rehabilitated, it must be concluded that baseline complement levels and function are depressed in mild-moderate malnutrition. However, when the presence of recent inflammatory processes was screened by elevation of C-reactive... 

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