Opioid treatment

Avidor-Reiss T, Bayewitch M, Levy R, Matus-Leibovitch N, Nevo I, Vogel Z. Adenylylcyclase supersensitization in mu opioid receptor transfected Chinese hamster ovary cells following chronic opioid treatment. J Biol Chem 1995 270 29732-29738. 

Avidor-Reiss T, Nevo I, Levy R, Pfeuf-fer T, Vogel Z. Chronic opioid treatment induces adenylyl cyclase V superactivation Involvement of G beta/gamma. J Biol Chem 1996 271 21309-21315. 

Subutex and Suboxone are unique not so much for their chemical makeup or mode of operation, but for the regulatory hurdles they overcame. Unlike other pharmacotherapies for heroin addiction (e.g, methadone, naltrexone, ORLAAM °), which can only be dispensed by specialized Opioid Treatment Clinics, specially-trained doctors are permitted to prescribe Subutex and Suboxone drugs in a standard office setting under the Drug Addiction Treatment Act (DATA) of 2000."... 

FDA approved alcohol and opioid treatment. Also being tested as a cocaine treatment Receptor blockers (antagonist)... 

The adverse reactions include slowing of gastrointestinal propulsion with the ensuing risk of constipation, which can be prevented with lactulose or lactitol. Opioid treatment can also cause nausea and sometimes vomiting. There is also a dependence problem and a risk of respiratory depression. The latter may be a practical problem in anaesthetic practice or in overdose, but rarely in the case of treatment with slowly increased oral doses. The nausea is... 

Some patients undergoing long-term opioid treatment develop a tolerance with loss of analgesic efficacy. The mechanisms behind this effect are likely to be multi-faceted and partly determined by individual factors. There is widespread and documented experience that the tolerance developed in a particular individual is not developed in parallel for different opioids. Different sources therefore recommend... 

Naltrexone Antagonist of opioid receptors Blocks effects of illicit opioids Treatment of alcoholism Half-life 4h... 

Opioids are used for the treatment of moderate to severe or very severe pain of acute or chronic type (Stein, 1999). Nearly all forms of pain are sensitive to opioid treatment and in contrast to traditional opinions even neuropathic pain is reasonably sensitive to higher doses of opioids. This was clearly shown in well-controlled clinical studies (Watson, 2000). The most important use of opioids in acute pain treatment is postoperative pain, whereas treatment of cancer pain, often accompanied by a neuropathic pain component, is the classical domain of chronic opioid treatment. 

Reduced motility and secretion can lead to constipation, which is the most common side-effect of chronic opioid treatment (Mancini and Bruera, 1998). Opioid-induced constipation can increase to the stage of megacolon or paralytic ileus. Therefore chronic opioid treatment should be accompanied by concomitant use of laxatives. Besides their peripheral actions, opioids are involved in the central... 

Brown, R. and Lo, R. The physical and psychosocial consequences of opioid addiction an overview of changes in opioid treatment, Aust. NZ J. Ment. Health Nurs. 2000, 9, 65-74. 

The responses of animal chronic neuropathic pain models to opioid treatment have often not mirrored this opioid resistance observed in clinic and thus the results have been controversial. Some researchers have found that opioids may... 

Niemann T, Madsen LG, Larsen S, Thorsgaard N. Opioid treatment of painful chronic pancreatitis. Int J Pancreatol 2000 27(3) 235-40. 

What are common adverse effects of opioid treatment ... 

Today the programs are referred to as Opioid Treatment Programs which are comprehensive maintenance programs for narcotic addicts. 

Terms frequently used in Opioid Treatment Programs include ... 

Interim maintenance treatment A time limited pharma-cotherapeutic regimen in conjunction with appropriate medical services while a patient awaits transfer to an Opioid Treatment Program that provides comprehensive maintenance treatment. 

Medication unit Facility established as part of, but geographically separate from an Opioid Treatment Program, from which certified private practitioners or community pharmacists may dispense or administer opioid agonist medications for observed ingestion. 

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