Opioid analgesic drugs clinical applications

The incorporation of glycosides into peptide neurotransmitters imparts drug-like character to the neurotransmitter message via membrane hopping . The importance of the gly-copeptide-membrane interaction is emphasized, and the biousian theory is briefly explained. Application of this approach to enkephalins, the endogenous opioid peptides, leads to potent analgesic compounds capable of systemic delivery. The clinical applications of these compounds are advocated by the author. 

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