Opiate receptors, autoradiographic localization

Pert CB, Kuhar MJ, Snyder SH (1976) Opiate receptor autoradiographic demonstration of localization in rat brain. Proc. Nat. Acad. Set USA, 73, 3729-3733. 

Moderate levels of CBi receptor are also found in several other regions of the midbrain. One of these is the periaqueductal gray (PAG) (Fig. 9C). Here CBi receptors are found on the terminals of GABAergic neurons. In contrast to opiate receptors on GABAergic aqueductal neurons, CBi receptors are preferentially localized in the dorsal portion of the PAG (Tsou et al. 1998a). Autoradiographic studies indicate that CBi receptors are also found at moderate levels in the reticular formation and raphe nucleus (Glass et al. 1997). 

Herkenham M, Pert CB (1982) Light microscopic localization of brain opiate receptors a general autoradiographic method which preserves tissue quality. J. Neuroscl, 2, 1129-1149. 

McLean S, Rothman RB, Herkenham M (1986) Autoradiographic localization of mu- and delta-opiate receptors in the forebrain of the rat. Brain Res., 378, 49-60. 

Adcock JJ (1991) Peripheral opioid receptors and the cough reflex. Respir Med 85 (Suppl A) 43 6 Ambalavanar R, Tanaka Y, Damiijian M et al. (1999) Laryngeal afferent stimulation enhances Fos immunoreactivity in periaqueductal grey in the cat. 1 Comp Neurol 409 411 23 Atweh SF, Kuhar Ml (1977) Autoradiographic localization of opiate receptors in rat brain. II. The brain stem. Brain Res 129 1-12... 

Fig. 3. The autoradiographic localization of opiate receptors in the rat spinal cord. This is a bright-field micrograph showing regions of the dorsal horn. Note the high concentrations of autoradiographic grains (hence, opiate receptors) over the substantia gelatinosa (sg), while there is a much lower level over Lissauer s tract (LT) and an intermediate level over lamina IV. (Reproduced from Atweh and Kuhar 1977a.)...

Atweh, S. F., and Kuhar, M. J., 1977a, Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla. Brain Res. 124 53-68. 

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